浸润性乳腺癌细胞学分级及其与激素受体等表达的关系

目的 探讨浸润性乳腺癌细胞分级的临床意义及其与雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子2(HER2)表达的关系.方法 对细针吸取细胞学(FNAC)诊断为"高度癌疑"及"乳腺癌"的47例细胞学标本进行细胞学分级,并采用免疫细胞化学方法检测细针吸取乳腺癌细胞ER、PR、HER2的表达,应用卡方检验对免疫细胞化学染色结果与术后免疫组织化学染色结果进行统计学分析,应用spearman相关分析对细胞学分级与ER、PR及HER2的表达关系进行统计学分析.结果 (1)术前穿刺涂片诊断为"高度可疑乳腺癌"及"乳腺癌"的47例女性患者,经术后病理组织学证实均为乳腺癌,细胞学诊断准确率为100%.其中1级13例,2级19例,3级15例.(2)利用免疫细胞化学染色对术前细针吸取细胞标本ER、PR及HER2表达进行检测,其阳性率分别为为55.32%、53.19%及19.15%.相对应的石蜡切片经免疫组织化学染色检测,ER、PR及HER2的表达阳性率55.32%、55.32%及17.02%.两种染色方法结果经卡方检验,差异无统计学意义(P>0.05).(3)术前乳腺癌细胞学分级与ER、PR的表达呈负相关(P＜0.01),与HER2的表达呈正相关(P＜0.01).结论 FNA是术前诊断乳腺癌准确、易行的方法之一.乳腺癌术前细针吸取细胞学分级联合免疫细胞化学染色可在术前提供更多肿瘤的相关信息,可能成为指导术前新辅助化疗、术式选择的有用指标.

Cytologic grading of invasive breast carcinoma and its correlation with the status of hormone receptors

Objective To evaluate the importance of cytologic grading of invasive breast carcinoma and its association with the status of ER,PR and HER2 on fine needle aspiration cytology(FNAC) material.Methods The cytologic grading was evaluated in 47 cases of breast carcinoma which were diagnosed as the FNAC.ER,PR and HER2 status,and were determined by immunocytochemistry on cytologic smears and compared with the histologic results by immunohistochemistry.The Correlation between cytologic grading and ER,PR and HER2 s...