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次声作用后血浆NO、ET-1、SOD、MDA水平的变化
引用本文:裴兆辉,陈景藻,朱妙章,裴建明,刘朝晖,谭永霞. 次声作用后血浆NO、ET-1、SOD、MDA水平的变化[J]. 中国病理生理杂志, 2005, 21(1): 188-190. DOI: 1000-4718
作者姓名:裴兆辉  陈景藻  朱妙章  裴建明  刘朝晖  谭永霞
作者单位:第四军医大学1基础部生理教研室,2预防医学系,3西京医院理疗与康复科, 陕西 西安 710032
基金项目:军队十五指令性课题(No.01L071)
摘    要:目的:测定8 Hz、130 dB次声不同时间暴露后大鼠血浆一氧化氮(NO)、内皮素(ET-1)、SOD、MDA水平的变化。方法:用8 Hz、130 dB的次声连续作用大鼠1、7、14、21和28 d,每天2 h,测定大鼠血浆NO、ET-1、SOD、MDA水平。结果:在暴露期间,7、14 d时大鼠血浆NO含量显著最低(P<0.01),1 d、21 d和28 d时正常(P>0.05);大鼠血浆ET-1含量均明显升高(P<0.01),7 d时升高最多,14 d时升高最少;大鼠血浆SOD活性明显降低(P<0.01);大鼠血浆MDA水平明显升高(P<0.01)。结论:次声可引起大鼠血浆NO、ET-1、SOD、MDA水平的变化,发生的改变与次声暴露时间有关。

关 键 词:次声  大鼠  一氧化氮  内皮缩血管肽1  丙二醛  超氧化物歧化酶  
文章编号:1000-4718(2005)01-0188-03
收稿时间:2003-06-30
修稿时间:2003-11-03

Plasma levels of endothelin-1, nitric oxide, malondialdehyde and superoxide dismutase in rats exposed to infrasound
PEI Zhao-hui,CHEN Jing-zao,ZHU Miao-zhang,PEI Jian-ming,LIU Zhao-hui,TAN Yong-xia. Plasma levels of endothelin-1, nitric oxide, malondialdehyde and superoxide dismutase in rats exposed to infrasound[J]. Chinese Journal of Pathophysiology, 2005, 21(1): 188-190. DOI: 1000-4718
Authors:PEI Zhao-hui  CHEN Jing-zao  ZHU Miao-zhang  PEI Jian-ming  LIU Zhao-hui  TAN Yong-xia
Affiliation:1Department of Physiology, School of Basic Medicine,2School of Preventive Medicine,3Department
of Physic Therapy & Rehabilitation, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Abstract:AIM: To observe the changes of NO, ET-1, SOD and MDA levels in plasma of rats exposed to infrasound. METHODS: Using infrasound (frequency: 8 Hz; sound pressure level:130 dB), the rats were exposed for 1 d, 7 d, 14 d, 21 d and 28 d, 2 h daily, then the levels of NO, ET-1, SOD and MDA were measured after exposure. RESULTS: The changes of NO levels in plasma significantly declined at 7 d and 14 d (P<0.01), then 1, 21 and 28 d normally (P>0.05). The changes of ET-1 levels in all groups in plasma were significantly increased (P<0.01), mostly at 7 d, least at 14 d. The changes of SOD activity in all groups in plasma were significantly declined (~P<0.01 ). The changes of MDA levels in all groups in plasma were significantly increased (P<0.01). CONCLUSIONS: Infrasouns induces changes of NO, ET-1, SOD and MDA in rat plasma, and it depends on infrasound exposure time. [
Keywords:Infrasound  Rats  Nitric oxide  Endothelin-1  Malondialdehyde  Superoxide dismutase
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