| 次声作用后血浆NO、ET-1、SOD、MDA水平的变化 |
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| 引用本文： | 裴兆辉,陈景藻,朱妙章,裴建明,刘朝晖,谭永霞. 次声作用后血浆NO、ET-1、SOD、MDA水平的变化[J]. 中国病理生理杂志, 2005, 21(1): 188-190. DOI: 1000-4718 |
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| 作者姓名： | 裴兆辉 陈景藻 朱妙章 裴建明 刘朝晖 谭永霞 |
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| 作者单位： | 第四军医大学1基础部生理教研室，2预防医学系，3西京医院理疗与康复科， 陕西 西安 710032 |
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| 基金项目： | 军队十五指令性课题(No.01L071) |
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| 摘 要： | 目的：测定8 Hz、130 dB次声不同时间暴露后大鼠血浆一氧化氮（NO）、内皮素（ET-1）、SOD、MDA水平的变化。方法：用8 Hz、130 dB的次声连续作用大鼠1、7、14、21和28 d，每天2 h，测定大鼠血浆NO、ET-1、SOD、MDA水平。结果：在暴露期间，7、14 d时大鼠血浆NO含量显著最低（P＜0.01），1 d、21 d和28 d时正常（P＞0.05）；大鼠血浆ET-1含量均明显升高（P＜0.01），7 d时升高最多，14 d时升高最少；大鼠血浆SOD活性明显降低（P＜0.01）；大鼠血浆MDA水平明显升高（P＜0.01）。结论：次声可引起大鼠血浆NO、ET-1、SOD、MDA水平的变化，发生的改变与次声暴露时间有关。
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| 关 键 词： | 次声 大鼠 一氧化氮 内皮缩血管肽1 丙二醛 超氧化物歧化酶 |
| 文章编号： | 1000-4718(2005)01-0188-03 |
| 收稿时间： | 2003-06-30 |
| 修稿时间： | 2003-11-03 |
Plasma levels of endothelin-1, nitric oxide, malondialdehyde and superoxide dismutase in rats exposed to infrasound |
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| PEI Zhao-hui,CHEN Jing-zao,ZHU Miao-zhang,PEI Jian-ming,LIU Zhao-hui,TAN Yong-xia. Plasma levels of endothelin-1, nitric oxide, malondialdehyde and superoxide dismutase in rats exposed to infrasound[J]. Chinese Journal of Pathophysiology, 2005, 21(1): 188-190. DOI: 1000-4718 |
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| Authors: | PEI Zhao-hui CHEN Jing-zao ZHU Miao-zhang PEI Jian-ming LIU Zhao-hui TAN Yong-xia |
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| Affiliation: | 1Department of Physiology, School of Basic Medicine,2School of Preventive Medicine,3Department
of Physic Therapy & Rehabilitation, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China |
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| Abstract: | AIM: To observe the changes of NO, ET-1, SOD and MDA levels in plasma of rats exposed to infrasound. METHODS: Using infrasound (frequency: 8 Hz; sound pressure level:130 dB), the rats were exposed for 1 d, 7 d, 14 d, 21 d and 28 d, 2 h daily, then the levels of NO, ET-1, SOD and MDA were measured after exposure. RESULTS: The changes of NO levels in plasma significantly declined at 7 d and 14 d (P<0.01), then 1, 21 and 28 d normally (P>0.05). The changes of ET-1 levels in all groups in plasma were significantly increased (P<0.01), mostly at 7 d, least at 14 d. The changes of SOD activity in all groups in plasma were significantly declined (~P<0.01 ). The changes of MDA levels in all groups in plasma were significantly increased (P<0.01). CONCLUSIONS: Infrasouns induces changes of NO, ET-1, SOD and MDA in rat plasma, and it depends on infrasound exposure time. [ |
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| Keywords: | Infrasound Rats Nitric oxide Endothelin-1 Malondialdehyde Superoxide dismutase |
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