首页 | 本学科首页   官方微博 | 高级检索  
     


Glutathione S-transferase polymorphisms associated with risk of breast cancer in southern Taiwan
Authors:Chang Tsai-Wang  Wang Shuei-Ming  Guo Yue-Liang L  Tsai Pei-Chien  Huang Chien-Jung  Huang Wenya
Affiliation:Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Abstract:In this study, the genetic polymorphisms associated with breast cancer in southern Taiwan were investigated. Two categories of genes were analyzed: (1) BRCA1, BRCA2, and Rad51, the DNA repair factors involved in homologous recombinational repair; and (2) CYP1A1, COMT, GST, and NAT2, the xenobiotic-metabolizing enzymes (XME) involved in estrogen metabolism. We found that the number of deletions and/or mutations in the GST genes was highly correlated with the occurrence of breast cancer. These data suggest that the GST enzymes, which detoxify the catechol estrogen quinones, are important target molecules for screening in populations at high risk of breast cancer.
Keywords:Breast cancer   Glutathione s-transferase   BRCA   Homologous recombination   DNA damage and repair
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号