| 宫颈癌刮片细胞CEA免疫细胞化学研究 |
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| 引用本文： | 宗安民,史学义,孟爱民,吴景兰,王克聪,王福丰,张风芝.宫颈癌刮片细胞CEA免疫细胞化学研究[J].肿瘤基础与临床,1992(3). |
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| 作者姓名： | 宗安民 史学义 孟爱民 吴景兰 王克聪 王福丰 张风芝 |
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| 作者单位： | 河南医科大学组织胚胎学教研室，河南医科大学组织胚胎学教研室，河南医科大学组织胚胎学教研室，河南医科大学组织胚胎学教研室，河南医科大学三附院妇产科，河医大一附院，郑州国棉五厂职工医院 |
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| 摘 要： | 本文应用SPA-HRP(辣根过氧化物酶标记的金黄色葡萄球菌蛋白A)免疫组织化学技术对14例宫颈癌和6例非宫颈癌的刮片细胞进行了CEA免疫反应性(IR)观察。结果见97％的癌细胞呈CEA-IR,且反应较强;大多数非典型增生细胞亦呈CEA-IR,并见有少数正常宫颈上皮细胞星弱CEA—IR。以上三者的CEA-IR有显著性差异。文中讨论了宫颈刮片细胞CEA免疫细胞化学检测对宫颈癌早期诊断的辅助价值及其对特异CEA抗体导向的局部抗宫颈癌治疗的意义。
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| 关 键 词： | 宫颈癌 癌胚抗原 免疫细胞化学 |
Study on CEA Immunocytochemistry in the Cell Specimen Scraped from the Cervical Carcinoma |
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| Zong Anmin,et al.Study on CEA Immunocytochemistry in the Cell Specimen Scraped from the Cervical Carcinoma[J].journal of basic and clinical oncology,1992(3). |
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| Authors: | Zong Anmin |
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| Institution: | Zong Anmin,et al Department of Histology & Ernbryology,Henan Medical University,Zhengzhou,450052 |
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| Abstract: | Using SPA-HRP immunohistochemical technique for CEA detection the cell specimen scraped from 14 cases of cervical carcinoma and 6 cases of nonmalignant cervix were observed in comparasion. It was found that 97% of the cancer cells showed CEA immunoreactivity with stronger intensity; most dysplasia cells showed CEA immunoreactivity also and a weak CEA immunoreactivity was present in a few epithelial cells in normal cervix. Among them there was a significant difference in CEA immunoreactivity. In this paper the significance of CEA immunochemical detection from cervical scraping used as an adjunct to early diagnosis of cervical carcinoma and as a backing for local therapy with specific CEA antibody against the cervical cancer cells was discussed. |
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| Keywords: | cervical carcinoma CEA immunocytochemistry |
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