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Graded ephrin-A2 expression in the developing hamster superior colliculus |
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| Authors: | Sherralee S. Lukehurst Carolyn E. King Lyn D. Beazley David K. C. Tay Kwok-Fai So Jennifer Rodger |
| Affiliation: | (1) School of Animal Biology M092, The University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia;(2) Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong and State Key Laboratory on Brain and Cognitive Sciences, Pokfulam, Hong Kong, China;(3) Western Australian Institute for Medical Research, The University of Western Australia, Crawley, WA, Australia |
| Abstract: | During development, ephrin gradients guide retinal ganglion cell axons to their appropriate topographic locations in the superior colliculus (SC). Expression of ephrin-A2, assessed immunohistochemically in the developing hamster SC, revealed a rostrallow to caudalhigh gradient that is most prominent at postnatal days (P)4 and P7 when topography is established. Double-labelling immunohistochemistry for ephrin-A2 and cell specific markers revealed that ephrin-A2 is expressed exclusively by a subset of neurons. The expression pattern has implications for mechanisms underlying establishment of topography during development and following injury. |
| Keywords: | Ephrin-A2 Superior colliculus Retinal ganglion cells Retinotectal topography Neurons |
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