头颈CTA中基于复合体重因子的对比剂剂量应用

目的:探讨基于复合体重因子的对比剂使用方法行头颈CTA的可行性。方法:实验组40例患者采用基于复合体重因子的对比剂使用方法在Toshiba Aquilion ONE 320容积CT上行头颈CTA,对照组26例患者采用基于体重的对比剂使用方法在同一台螺旋CT上行头颈CTA。采用独立样本t检验比较实验组和对照组的对比剂剂量、辐射剂量和主动脉弓、右颈总动脉、右颈内动脉、右椎动脉、基底动脉、大脑后动脉、大脑中动脉、大脑前动脉的CT值与其强化差值、图像信噪比、对比噪声比;采用双盲法对图像进行主观评价,并采用Mann-Whitney U检验比较两组的图像质量。结果:实验组和对照组的对比剂剂量分别为(55.4±5.9)mL/例、(62.8±7.9)mL/例,两组的对比剂剂量有显著差异(P<0.05)。实验组和对照组的辐射剂量(DLP)均值分别为(489.1±55.0)mGy·cm、(555.6±78.7)mGy·cm。实验组和对照组的辐射剂量有显著差异(P<0.05)。实验组考察的动脉CT值和动脉强化差值均高于对照组且差异具有统计学意义(P<0.05)。实验组和对照组的图像信噪比、对比噪声比无统计学差异(P>0.05)。实验组的图像主观评价好于对照组且有统计学意义(U检验,P<0.05)。结论:采用基于复合体重因子的对比剂使用方法结合低管电压技术在行头颅CTA时可以在保证图像质量、满足临床诊断需求的前提下降低对比剂用量、降低辐射剂量。

The application of the technology of contrast agents based on compound body weight factor in head and neck CTA

Objective:To investigate the feasibility of the protocol of contrast agents based on compound body weight factor in head and neck combined CT angiography(HNCTA).Methods:Forty patients served as the experimental group underwent HNCTA with the contrast protocol of compound body weight factor.Twenty-six patients served as controls with the contrast protocol based on weight.An independent sample t-test was used to compare the dose of contrast agent,radiation dose,and CT values of aortic arch,right common carotid artery,right internal carotid artery,right vertebral artery,basilar artery,posterior cerebral artery,middle cerebral artery and anterior cerebral artery between the experimental group and the control group.The differences of contrast,image signal-to-noise ratios and contrast noise ratios were also compared between the two groups.Subjective evaluation was performed by using a double-blind method,and Mann-Whitney U tests were used to compare the image quality of the two groups.Results:The mean contrast agent dose was(55.4±5.9)mL/case in the experimental group and(62.8±7.9)mL/case in the control group,respectively(P<0.05).The mean radiation dose(DLP)was(489.1±55.0)mGy·cm in the experimental group and(555.6±78.7)mGy·cm in the control group,respectively(P<0.05).The CT values of arteries and the contrast differences of arteries were significantly higher in the experimental group than those in the control group(P<0.05).There was no statistical difference in the signal-to-noise ratio and contrast noise ratio between the two groups(P>0.05).The subjective evaluation of images in the experimental group was better than that of the control group(U test,P<0.05).Conclusions:The protocol of contrast agent based on compound body weight factor can obtain diagnostic image quality while reducing the dose of contrast agent in HNCTA.