CXC趋化因子配体3与相关疾病的研究进展

CXC趋化因子配体(CXCL)3是由多种细胞分泌的一种低相对分子质量的生物活性蛋白质,主要通过招募和活化多种表达CXC趋化因子受体(CXCR)1、2的细胞,参与细胞迁移、侵袭及血管新生等调控,在妊娠相关疾病、肿瘤、心血管疾病及肺部疾病发生、发展中具有重要作用。阻断CXCL3或CXCR1、2信号传导通路,可抑制细胞迁移、侵袭、血管生成、肿瘤发生及纤维化等病理生理过程,这可能成为多种疾病的潜在防治靶点。笔者拟就CXCL3与妊娠相关疾病、肿瘤、心血管疾病及肺部疾病关系的最新研究进展进行阐述,旨在发现CXCL3在上述疾病发病机制中的具体作用,为临床采取新策略诊断及分子靶向治疗上述疾病提供参考。

Research progress of relationship between CXC chemokine ligand 3 and related diseases

CXC chemokine ligand (CXCL)3 is one of low relative molecular mass bioactive proteins, secreted by various kinds of cells. CXCL3 plays a pivotal role in the occurrence and development of pregnancy-associated diseases, tumors, cardiovascular diseases, and lung disorders which may be associated with its participation in the regulation of cell migration, cell invasion, vasculogenesis and so on by recruiting and activating different kinds of cells which express CXC chemokine receptor (CXCR)1/2. Blocking CXCL3 or CXCR1/2 signal transduction pathways could inhibit such pathophysiological processes as cell migration, cell invasion, angiogenesis, tumorigenesis and fibration and may be the potential targets in the prevention and treatment of multiple diseases. Therefore, this paper reviews the latest research progresses of the relationship between CXCL3 and pregnancy-associated diseases, tumors, cardiovascular diseases, and lung disorders, with the aim to reveal the concrete functions of CXCL3 in the pathogenesis of these disorders and to provide a basis for adopting new diagnosis strategies and molecular targeted therapy for these diseases.