生物标志物指导下的抗肿瘤药物研发 |
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引用本文: | 邱国玉,许晓辉,贾汝玲,党子龙,马友振.生物标志物指导下的抗肿瘤药物研发[J].转化医学杂志,2020,9(3):190-封三. |
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作者姓名: | 邱国玉 许晓辉 贾汝玲 党子龙 马友振 |
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作者单位: | 甘肃 兰州,兰州市食品药品检验所中药室;甘肃 兰州,兰州大学第一医院药学部;江苏 徐州,江苏万邦生化医药集团有限责任公司药物研发中心 |
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摘 要: | 生物标志物已成为抗肿瘤药物研究与开发的关键要素,越来越多的信号分子和通路被确证为抗肿瘤药物的治疗靶点,寻找和发现有价值的抗肿瘤药物活性预测生物标志物已经成为目前抗肿瘤药物研发的热点。生物标志物作为一种探针能够指示抗肿瘤药物的生物药理活性,对精准研发抗肿瘤药物活性与临床试验具有很好的预测性,生物标志物指导下的抗肿瘤药物研发能够降低药物研发失败的风险。作者综述了基于生物标志物的抗肿瘤药物导向预测研究,旨在抗肿瘤药物研发过程中,合理的选择生物标志物,提高抗肿瘤药物研发的精准性。
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关 键 词: | 生物标志物 抗肿瘤药物 |
Anticancer drug research and development based on biomarkers |
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Authors: | QIU Guoyu XU Xiaohui JIA Ruling DANG Zilong MA Youzhen |
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Institution: | Department of Traditional Chinese Medicine, Lanzhou Institutes for Food and Drug Control,Lanzhou Gansu 730050, China;Department of Pharmacy, First Hospital of Lanzhou University,Lanzhou Gansu 730000, China; The Centre of Pharmaceutical Research & Development,Jiangsu Wanbang Biochemical Pharmaceutical Group Co. LTD, Xuzhou Jiangsu 221004, China |
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Abstract: | Biomarkers have become a key factor in the research and development of anticancer drugs. More and more signal molecules and pathways have been identified as the therapeutic targets of anticancer agents. The search and discovery of valuable biomarkers has become a hotspot in research and development of anticancer drugs. As a probe, biomarker can indicate the biological pharmacological activity of anticancer drug, which is highly predictive of the precise research and development of anticancer drug activity and clinical trial. The research and development of anticancer drug under the guidance of biomarkers can reduce the risk of failure in drug research and deve lopment. This paper reviews the research on the prediction of the efficacy of anticancer drug based on biomarkers. In the process of the development of anticancer drug, reasonable selection of biomarkers can improve the accuracy of the development in anticancer drug. |
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Keywords: | Biomarker Anticancer drug |
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