初诊2型糖尿病患者微量白蛋白尿的发生率及相关因素分析

目的探讨初诊2型糖尿病(T2DM)患者微量白蛋白尿(MAU)的发生率及其影响因素。方法初诊T2DM患者86例,按尿白蛋白排泄率分为正常白蛋白尿(NAU)组和微量白蛋白尿(MAU)组。检测所有患者的空腹血糖(FBG)、餐后2h血糖(P2hBG)、糖化血红蛋白(HbA1 c)、血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(apoA1)和载脂蛋白B(apoB)。结果初诊T2DM患者MAU发生率为32.56%,合并高血压者MAU发生率为40.00%。MAU组FBG、P2hBG和HbA1 c均高于NAU组,有统计学意义(P<0.05)。MAU组TG、TC均高于NAU组,但无统计学意义(P>0.05)。LDL-C、HDL-C、apoA1和apoB在两组间无差异。结论初诊T2DM患者MAU发生率主要与糖代谢指标和血压有关,早期诊断糖尿病并干预治疗对预防糖尿病慢性并发症十分重要。

Analysis on Incidence of Microalbuminuria in Preliminarily Diagnosed Patients of Type 2 Diabetes and Its Related Factors

Objective To discuss the incidence of microalbuminuria(MAU) in preliminary diagnosed patients of type 2 diabetes and its influenced factors.Method 86 preliminarily diagnosed patients of type 2 diabetes were divided into 2 groups(normal albuminuria group and microalbuminuria group) according to urinary albumin excretion rate.Fasting plasma glucose(FBG),postgrandial 2h glucose(P2hBG),glycosylated hemoglobin(HbA1c),triglyceride(TG),total cholesterol(TC),low density lipid cholesterol(LDL-C),high density lipid cholesterol(HDL-C),apoprotein A_1(aproA_1) and apoprotein B(apoB) were measured in all cases.Results The incidence of MAU was 32.56% in preliminanily diagnosed patients of type 2 diabetes,while it was 40.0% in patients complicated with hypertension.FBG,P2hBG and HbA1c in MAU group were higher than those in normal albuminuria group,there was a statistical significance(P<0.05).The levels of TG and TC in MAU group were higher than those in normal albuminuria group,but there was no statistical significance(P>0.05).There were no difference in LDL-C,LDL-C,apoA_1 and apoB between two groups.Conclusions The incidence of MAU in preliminarily diagnosed patients of type 2 diabetes is mainly associated with glycometabolism and blood pressure.Early diagnosis and intervention of diabetes are important to the prevention of chronic diabetic complications.