缺血心肌动物模型PET和SPECT显像及组织学对比研究

目的评估^201TI SPECT及^18F-脱氧葡萄糖（FDG）PET显像对模型猪心肌活力的鉴别。方法健康家猪12头，其中10头于冠状动脉左旋支起始处放置Ameriod环，饲养28d形成慢性心肌缺血动物模型（另2头作正常对照），行^201TI SPECT心肌灌注显像和^18F—FDG PET心肌代谢显像并与HE染色病理学改变进行比较。结果81个心肌节段中，^18F—FDG心肌显像示心肌有活力的节段为73个（90．1％），明显高于^201TI心肌显像所示的62个（76．5％），差异有显著性（P〈0．05）。HE染色结果示有心肌活力的节段为74个（91．3％），与^18F—FDG心肌显像所示结果差异无显著性（P〉0．05）。结论^18F—FDGPET心肌显像检测心肌活力的准确性明显高于^201TI SPECT心肌显像。

The comparative study of PET, SPECT imaging and pathology on experimental animal model of myocardial ischemia

Objective To compare 201Tl SPECT and 18F-fluorodeoxyglucose ( FDG) PET imaging for the assessment of myocardial viability of chronic myocardial ischemia in pigs. Methods 201Tl SPECT imaging and F-FDG PET imaging were performed on 10 pig models of chronic myocardial ischemia induced by ameroid constrictors. The viable myocardial segments were also determined by pathologic hemotoxylin and e-osin (HE) staining to identify myocardial changes. Results In 81 myocardial segments, viable myocardial segments assessed by 18F-FDG PET and 201T1 SPECT imaging were 73(90. 1% ) and 62(76. 5% ) respectively, and were statistically different (X2 =5. 37 ,P <0. 05) , whereas in HE staining, the viable myocardial segments identifed were 74(91. 3% ). Comparing 18F-FDG PET imaging with HE staining, no statistic difference was found (X2= 0. 073 , P > 0.05). Conclusion The accuracy of 18F-FDG PET imaging was much more higher than 201Tl SPECT imaging for the assessment of viable myocardium.