Quantitative structure activity relationships and mixture toxicity studies of alcohols and chlorohydrocarbons: Effects on growth of Daphnia magna |
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| Authors: | Joop Hermens Els Broekhuyzen Hans Canton Ronald Wegman |
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| Institution: | 1. Department of Veterinary Pharmacology, Pharmacy and Toxicology, P.O. Box 80176, 3508 TD Utrecht, The Netherlands;2. National Institute of Public Health, P.O. Box 1, 3720 BA Bilthoven, The Netherlands |
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| Abstract: | Effects on growth of Daphnia magna were studied for 10 non-reactive organic chemicals such as alcohols and chlorobenzenes. The ‘no observed effect concentration’ (NOEC) was very well correlated with the hydrophobicity (Poct) of the tested compounds which appeared in a quantitative structure-activity relationship (QSAR) study. With this QSAR the NOEC for 15 other compounds was predicted. The joint toxicity of mixtures of 10 and 25 compounds was also tested. The NOEC of these mixtures was predictable on the basis of concentration-additivity. |
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| Keywords: | structure-activity relationship complex mixtures |
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