High rate of seroconversion following administration of a single supplementary dose of recombinant hepatitis B vaccine in Iranian healthy nonresponder neonates |
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| Authors: | F Shokri Abdollah Amani |
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| Institution: | (1) Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, P.O. Box 6446-14155, I.R. Iran Fax: 98-21-646-2267, IR;(2) Blood Transfusion Center of Sanandaj, Sanandaj, I.R. Iran, IR |
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| Abstract: | Forty-nine Iranian neonates who failed to develop a protective anti hepatitis B surface antigen (HBs) response following
primary vaccination with triple doses of recombinant hepatitis B vaccine, were classified as hypo-responders (anti-HBs > 1
< 10 IU/l) or non-responders (anti-HBs < 1 IU/l) and subsequently challenged with a single supplementary vaccine dose. A protective
and anamnestic type of response was observed in 90% (44/49) of the neonates. The mean titer of anti-HBs antibody was significantly
higher following supplementary vaccination, compared to that achieved after primary vaccination. This was more evident in
the primary hypo-responder neonates (P < 0.00001) than the non-responder group (P < 0.002). The results indicate that a significant proportion of the non-responder neonates to HBs antigen can be induced
to develop a protective and long-lasting antibody response by administration of a single additional vaccine dose.
Received: 24 September 1996 |
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| Keywords: | Hepatitis B virus Vaccination Antibody to hepatitis B surface antigen Seroconversion |
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