| 几种常用辅料在复方中药制剂中阻湿性能的比较 |
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| 引用本文： | 尹晓琴,顼佳音,杜林娇,陈燕军.几种常用辅料在复方中药制剂中阻湿性能的比较[J].中国中药杂志,2013,38(14):2297-2301. |
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| 作者姓名： | 尹晓琴 顼佳音 杜林娇 陈燕军 |
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| 作者单位： | 中国中医科学院 中药研究所, 北京 100700;中国中医科学院 中药研究所, 北京 100700;中国中医科学院 中药研究所, 北京 100700;中国中医科学院 中药研究所, 北京 100700 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09301-005-05);国家中医药管理局中医药科技研究专项(2011ZX09201-201-26) |
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| 摘 要： | 目的: 比较几种常用辅料在复方中药制剂中的阻湿性能。 方法: 该研究以吸湿率和其他吸湿特性参数为指标,以复方中药制剂1,2为模型药物,比较了7种辅料(糊精、磷酸氢钙、微晶纤维素、乳糖、乙基纤维素、甘露醇、HPMC)的阻湿性能。 结果: 复方中药制剂1吸湿平衡时的吸湿率为62.54%,临界相对湿度为38%;复方中药制剂2吸湿平衡时的吸湿率为16.36%,临界相对湿度为53%;以复方中药制剂1,2为目标参照物加入各种阻湿剂后均能不同程度的降低其吸湿率,在复方中药制剂1中,各辅料吸湿初速度由小到大次序为糊精<磷酸氢钙<微晶纤维素<乳糖<乙基纤维素<甘露醇结论: 在制备以复方中药为原料的制剂时,应根据物料和阻湿剂的性质来选择适当的阻湿剂。该试验为复方中药制剂的研制与开发提供了实验数据。
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| 关 键 词： | 复方中药制剂 吸湿率 吸湿特性参数 复方中药 |
| 收稿时间： | 2013/3/31 0:00:00 |
Influence of several excipients on damp-proof performance of pharmaceutical materials of traditional Chinese medicine |
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| YIN Xiao-qin,XU Jia-yin,DU Lin-jiao and CHEN Yan-jun.Influence of several excipients on damp-proof performance of pharmaceutical materials of traditional Chinese medicine[J].China Journal of Chinese Materia Medica,2013,38(14):2297-2301. |
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| Authors: | YIN Xiao-qin XU Jia-yin DU Lin-jiao and CHEN Yan-jun |
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| Institution: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China |
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| Abstract: | Objective: To study the influence of several excipients on damp-proof performance of pharmaceutical materials of traditional Chinese medicine. Method: The moisture absorption rate and parameters of hydroscopicity were used as the evaluation index of the damp-proof property of the complex Chinese medicine and preparation 1 and 2. Result: The moisture rate of complex Chinese medicine 1 was 62.54%, the critical relative humidity (CRH) was 38%. The moisture rate of complex Chinese medicine 2 was 16.36%, the CRH was 53%. Excipients had different effect on lower the hyproscopic property of complex Chinese medicine 1 and 2. The initial moisture adsorption velocity of excipients of complex Chinese medicine 1 in a ascending order were dextrinConclusion: The choosing of damp-proof excipients of preparation based on the property of the complex traditional Chinese medicine. The study provided experimental evidences for the research and development of the pharmaceutical materials of traditional Chinese medicine. |
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| Keywords: | pharmaceutical materials of traditional Chinese medicine moisture absorption rate parameters of hydroscopicity complex Chinese medicine |
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