新生儿败血症107例临床分析

目的：对新生儿败血症进行早期诊断，减少并发症，降低病死率。方法：对我院近10年来107例血培养阳性患儿的临床资料进行分析。结果：新生儿败血症临床表现无特殊性，并发症多，未梢血象、C反应蛋白均不能作为诊断依据。血培养仍是确诊的主要手段，但阳性率不高。病原菌以金黄色葡萄球菌（24．29％）为主，四联球菌（21．50％）为次，机会菌感染占50．46％。病死率以鼠伤寒沙门氏菌、大肠杆菌所致为高，分别是43．75％、33．33％。目前病原菌普遍敏感的抗生素有头孢唑啉、头孢哌酮、丁胺卡那霉素、万古霉素。结论：对拟诊病例开展L型血培养，以提高诊断率。早期应用敏感抗素控制感染，积极防治并发症，减少病死率。

Clinical Analysis of 107 Neonates With Septicemia

Objective:To diagnose neonatal septicemia in early stage so as to reduce complications and decrease mortality.Methods:Clinical data were analyzed in 107 neonatal septicemia cases with positive blood culture in recent ten years.Results:Neonatal septicemia had various complications,but no specific clinical manifestation.The diagnosis can not be based on either white cell count or C-reacting protein.Blood culture was still the key means of diagnosis,but the positive rate was not very high.The main pathogen causing septicemia was staphylococcus aureus (24.29%),tetrads(21.50%) and opportunist(50.46%).Mouse bacillus typhosus and colon escherichia infection contributed to a higher mortality,accounting for 43.75% and 33.33% respectively.The Principal sensitive medicine seems still to be cefazolin,cefobid,amikacin,vancomycin.Conclusion: Type L-blood culture should be performed in the susceptible cases.The sensitive medicine should be given in early stage to cure infection,reduce complication and decrease mortality.