Warfarin-induced leukocytoclastic vasculitis |
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Authors: | Yaghoubian Bahareh Ngo Binh Mak May Ostrzega Enrique Tesoro Jane Mitani Gladys H Moriguchi |
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Affiliation: | Ambulatory Care Pharmacy, University of Southern California School of Pharmacy, Los Angeles, CA 90033, USA. |
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Abstract: | Skin reactions associated with oral coumarin-derived anticoagulants are an uncommon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 patients with late-onset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed after receiving warfarin for several years. The results of skin lesion biopsies were available in 3 patients, confirming LV Cutaneous lesions resolved in all patients after warfarin was discontinued. In 2 of the 4 patients, rechallenge with warfarin led to recurrence of the lesions. LV may be a late-onset adverse reaction associated with warfarin therapy. |
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