雷尼酸锶对尾吊大鼠失重性骨质疏松的防治作用

目的观察雷尼酸锶(SR)对尾吊大鼠血清骨代谢指标、骨密度、骨生物力学的影响。方法选用3月龄雄性健康SD大鼠30只,随机分为5组:全程对照组(A组)、尾吊时服用SR组(B组)、尾吊后服用SR组(C组)、全程服用SR组(D组)、尾吊后对照组(E组),共8周(其中尾吊4周)。分别检测血清骨代谢指标,行骨密度检查及骨生物力学实验。结果尾吊后对照组碱性磷酸酶和骨钙素活性明显高于其余各组(P0.05)。骨密度、最大压缩载荷、最大三点弯曲载荷均比A组低,经过SR治疗后各组指标均有不同程度提高(P0.05),但尾吊后服用SR组和全程服用SR组效果相当且优于尾吊时服用SR组。结论雷尼酸锶对尾吊大鼠骨质疏松有防治作用。

Effects of strontium ranelate on osteoporosis in simulated weightlessness rats

Objective To observe the effects of strontium ranelate (SR) on simulated Weightlessness male rats.Methods 30 three-month-old male SD rats were randomly divided into 5 groups:whole rang control group(group A),SR intervention when tailing suspension group(group B),SR intervention after tail suspension group(group C),SR intervention all the time group(group D)and control group after tail suspension(group E).The experiment lasted 8 weeks(tail suspension with 4 weeks).The serum Ca,P,alkaline phosphatase(ALP)and bone gla protein(BGP) were assayed.Bone mineral density(BMD)was examined by DEXA,and the maximum compress load,maximum three point bending load of femur and lumbar were tested.Results In the rats of group E,ALP and BGP were significantly higher than the rest groups (P＜0.05).BMD,maximum compress load、maximum three point bending load all lower than group A(P＜0.05).Group C and group D show the equivalent effect after treated by SR,and both of them supass group B.Conclusion There were the preventive and therapeutic effects on osteoporosis in simulated weightlessness rats by strontium ranelate.