伴发与非伴发迟发性运动障碍的慢性精神分裂症患者认知状况比较分析

目的探讨伴发与非伴发迟发性运动障碍(TD)的慢性精神分裂症患者认知状况间存在的差异及可 能的机理。方法采用成人书氏智力(WAIS)、韦氏记忆(WMS)、威斯康星卡片分类测验(WCST)、词汇流畅性 (VFT)、Stroop测验(WCT),对一般状况匹配的伴发(53例,TD组)与非伴发(55例,非TD组)TD慢性精神分裂症 患者进行检测,以综合评定2组患者认知功能,比较其认知损伤的差异。结果在WAIS操作、言语及全量表智商、 WMS的记忆商、VFT的所有指标上,TD组显著差于非TD组(P<0．05);而2组在WCST除完成分类数外的其他指 标及WCT的各指标的差异均未达到显著水平(P>0．05)。结论伴发TD的慢性精神分裂症患者的认知功能损伤 更明显,这可能与抗精神病药导致的神经元改变有关。

Comparison of cognitive state in schizophrenic patients between with and without tardive dyskinesia

Objective To investigate differences between chronic schizophrenic patients with and without tardive dyskinesia(TD) in cognitive function and the possible mechanism. Methods To evaluate cognitive state of the chronic schizophrenic with TD( n =53 , TD group) and without TD(n =55 , without TD group) by using Wechlors Adult Intelligence Scale (WAIS) , Wechlors Memory Scale ( WMS) .Wisconsin cards sorting test ( WCST) .Verbal fluency test ( VFT) , Stroop's test(WCT) , compare the performances between two groups in these tests. Results The schizophrenia with TD compared with those without TD on these tests, performances of damages of the patients with TD were more serious, and it was significant on verbal,operational and full intelligence quotient of WAIS, memory quotient of WMS and all measures of VFT( P < 0. 05 ) , and no significances on main issues of WCST and WCT( P > 0. 05). Conclusions The deficits of cognitive function in patients with TD were more serious than those without TD, the pathophysiological factors might involve in neuron degeneration.