| 硝苯地平缓释片与普通片在健康人体内药动学的比较 |
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| 引用本文： | 葛文龙. 硝苯地平缓释片与普通片在健康人体内药动学的比较[J]. 中国新药与临床杂志, 2011, 0(9) |
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| 作者姓名： | 葛文龙 |
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| 作者单位： | 南通市中医院药剂科; |
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| 摘 要： | 目的比较硝苯地平缓释片与硝苯地平普通片在健康人体内药动学。方法 12名男性健康志愿者平均分为2组,分别单剂量口服硝苯地平缓释片与硝苯地平普通片20 mg,用高效液相色谱法检测硝苯地平的血药浓度,并用DAS 2.1软件进行数据处理。结果硝苯地平缓释片与硝苯地平普通片主要药动学参数ρmax分别为(1 247.8±78.4)μg.L-1和(1 896.7±109.2)μg.L-1,tmax分别为(4.6±0.7)h和(2.6±0.9)h,t1/2分别为(8.6±2.8)h和(4.8±1.5)h,AUC0-∞分别为(5 879.3±176.2)μg.h.L-1和(3 724.9±121.3)μg.h.L-1,AUC0-t分别为(4 427.8±131.7)μg.h.L-1和(2 936.5±75.4)μg.h.L-1。结论硝苯地平缓释片的tmax、t1/2长于普通片,AUC0-t、AUC0-∞高于普通片,而ρmax低于普通片,说明硝苯地平缓释片具有良好的缓释效果。
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| 关 键 词： | 硝苯地平 迟效制剂 血药浓度 药动学 |
Compare of pharmacokinetics of nifedipine sustained release tablets and nifedipine tablets in healthy volunteers |
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| GE Wen-long. Compare of pharmacokinetics of nifedipine sustained release tablets and nifedipine tablets in healthy volunteers[J]. Chinese Journal of New Drugs and Clinical Remedies, 2011, 0(9) |
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| Authors: | GE Wen-long |
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| Affiliation: | GE Wen-long(Department of Pharmacy,Nantong Municipal Hospital of Traditional Chinese Medicine,Nantong JIANGSU 226001,China) |
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| Abstract: | AIM To compare the pharmacokinetics of nifedipine sustained release tablets and nifedipine tablets in healthy volunteers.METHODS Twelve healthy male volunteers were divided into two groups,and received a single oral dose of nifedipine sustained release tablets and nifedipine tablets 20 mg,respectively.The plasma concentrations of nifedipine were determined by HPLC,and the pharmacokinetic parameters were calculated by DAS 2.1 software.RESULTS The pharmacokinetic parameters of nifedipine sustained release tab... |
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| Keywords: | nifedipine delayed-action preparations plasma drug concentration pharmacokinetics |
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