| 含四环素四联疗法作为一线方案根除幽门螺杆菌感染的疗效 |
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| 引用本文： | 何伟莉,叶斌,陈利坚,叶淑芳.含四环素四联疗法作为一线方案根除幽门螺杆菌感染的疗效[J].中国新药与临床杂志,2011(7). |
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| 作者姓名： | 何伟莉 叶斌 陈利坚 叶淑芳 |
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| 作者单位： | 丽水市中心医院消化科; |
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| 摘 要： | 目的观察埃索美拉唑、枸橼酸铋钾、四环素、甲硝唑四联疗法作为一线方案根除幽门螺杆菌(Hp)感染的疗效。方法将148例门诊Hp阳性的患者分为观察组(74例)使用埃索美拉唑、枸橼酸铋钾、四环素、甲硝唑四联抗Hp治疗。对照组(74例)使用埃索美拉唑、克拉霉素、阿莫西林三联疗法;疗程均为1wk。疗程结束4～8wk后复查胃镜或~(14)C呼气试验,检查Hp根除状况。结果观察组成功随访68例,其中62例Hp得到根除;按方案根除率为91%。对照组成功随访69例,42例Hp得到根除,按方案根除率为61%。2组根除率比较,差异有非常显著意义(P<0.01)。2组不良反应无显著差异(P>0.05)。结论含四环素的四联抗Hp治疗方案效果明显优于三联方案;在甲硝唑和克拉霉素高耐药的地区可以考虑作为一线治疗方案。
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| 关 键 词： | 螺杆菌 幽门 四环素 临床方案 埃索美拉唑 枸橼酸铋钾 甲硝唑 克拉霉素 阿莫西林 |
Efficacy of tetracycline-based quadruple therapy as first-line treatment for eradication of Helieobaeter pylori infection |
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| HE Wei-li,YE Bin,CHEN Li-jian,YE Shu-fang.Efficacy of tetracycline-based quadruple therapy as first-line treatment for eradication of Helieobaeter pylori infection[J].Chinese Journal of New Drugs and Clinical Remedies,2011(7). |
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| Authors: | HE Wei-li YE Bin CHEN Li-jian YE Shu-fang |
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| Institution: | HE Wei-li,YE Bin,CHEN Li-jian,YE Shu-fang (Department of Gastroenterology,Lishui Center Hospital,Lishui ZHEJIANG 323000,China) |
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| Abstract: | AIM To observe the efficacy and safety of 7 days of quadruple therapy with esomeprazole plus bismuth subcitrate potassium,metronidazole,and tetracycline(quadruple therapy) as first-line treatment for Helicobacter pylori(Hp) eradication in adults.METHODS A total of 148 out-patients with recorded Hp infection were assigned to trial group and control group.The patients in the trial group(n = 74) were treated with 7 days of quadruple therapy,and the patients in the control group(n = 74) were treated with 7 days... |
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| Keywords: | Helicobacter pylori tetracycline clinical protocols esomeprazole bismuth potassium citrate metronidazole clariehromycin amoxicillin |
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