| 不同pH值条件下蒙脱石散对配伍药物体外吸附作用的影响 |
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| 引用本文： | 陈爱瑛,叶小弟,程敏,缪云萍,方颖颖,郑高利.不同pH值条件下蒙脱石散对配伍药物体外吸附作用的影响[J].中国新药与临床杂志,2011(10). |
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| 作者姓名： | 陈爱瑛 叶小弟 程敏 缪云萍 方颖颖 郑高利 |
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| 作者单位： | 浙江省医学科学院药物研究所; |
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| 摘 要： | 目的研究在不同pH值人工胃液和人工肠液中蒙脱石散对常与其配伍药物诺氟沙星、氧氟沙星、萸连片、雷尼替丁、法莫替丁、阿昔洛韦、利巴韦林的体外吸附作用。方法取蒙脱石散分别加入到用不同pH人工胃液和人工肠液溶解的上述药物溶液中,用高效液相色谱法测定药物含量,计算吸附率。结果蒙脱石对萸连片中巴马汀、小檗碱的吸附率达95%以上;对诺氟沙星、氧氟沙星吸附率达80%左右;对阿昔洛韦、利巴韦林吸附率比较小,在10%以下;对法莫替丁和雷尼替丁的吸附率随着pH值的增加而降低。结论蒙脱石散对上述药物有不同的吸附作用,吸附率大的药物配伍应用时注意服药间隔时间。
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| 关 键 词： | 蒙脱石 硅酸铝类 药物疗法 吸附 |
Adsorption effects of montmorillonite powder on its compatible drugs at different pH values in vitro |
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| CHEN Ai-ying,YE Xiao-di,CHENG Min,MIAO Yun-ping,FANG Ying-ying,ZHENG Gao-li.Adsorption effects of montmorillonite powder on its compatible drugs at different pH values in vitro[J].Chinese Journal of New Drugs and Clinical Remedies,2011(10). |
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| Authors: | CHEN Ai-ying YE Xiao-di CHENG Min MIAO Yun-ping FANG Ying-ying ZHENG Gao-li |
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| Institution: | CHEN Ai-ying,YE Xiao-di,CHENG Min,MIAO Yun-ping,FANG Ying-ying,ZHENG Gao-li(Institute of Materia Medica,Zhejiang Academy of Medical Sciences,Hangzhou ZHEJIANG 310013,China) |
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| Abstract: | AIM To investigate the adsorption of montmorillonite powder interacting with its commonly used compatible drugs including norfloxacin,ofloxacin,Yulian tablets,ranitidine,famotidine,acyclovir and ribavirin in artificial gastric and intestinal fluid at different pH values in vitro.METHODS The artificial gastric and intestinal fluid at different pH values were used to dissolve the drugs,then montmorillonite powder was added into the drug solutions.The drug contents were determined by HPLC method,and the adsorp... |
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| Keywords: | montmorillonite aluminum silicates drug therapy adsorption |
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