| 叶酸受体介导的靶向纳米给药系统研究进展 |
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| 引用本文： | 陈焕蕾,刘秀菊,翟光喜. 叶酸受体介导的靶向纳米给药系统研究进展[J]. 中国新药与临床杂志, 2011, 0(7) |
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| 作者姓名： | 陈焕蕾 刘秀菊 翟光喜 |
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| 作者单位： | 山东大学药学院;山东省立医院西院药剂科; |
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| 基金项目： | 山东大学自主创新交叉学科课题(2010JC018); 国家自然基金(30973646) |
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| 摘 要： | 叶酸受体在许多恶性肿瘤细胞表面过度表达,而在正常细胞中则几乎不表达或只有少量表达。利用叶酸受体表达的特性,通过将叶酸修饰于药物载体表面,可使药物靶向输送至叶酸受体过度表达的肿瘤细胞中,从而避免对正常细胞产生毒性,提高药物疗效;而纳米给药系统因粒径较小等原因可使药物在肿瘤部位浓集。本文对近年来叶酸受体介导的靶向纳米给药系统进行了综述。
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| 关 键 词： | 叶酸 叶酸受体 药物释放系统 靶向给药 药物载体 |
Folate receptor mediated nano drug delivery systems |
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| CHEN Huan-lei,LIU Xiu-ju,ZHAI Guang-xi ,Ji-nan SH,ONG ,China). Folate receptor mediated nano drug delivery systems[J]. Chinese Journal of New Drugs and Clinical Remedies, 2011, 0(7) |
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| Authors: | CHEN Huan-lei LIU Xiu-ju ZHAI Guang-xi Ji-nan SH ONG China) |
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| Affiliation: | CHEN Huan-lei~1,LIU Xiu-ju~2,ZHAI Guang-xi~1 (1.College of Pharmacy,Shandong University,Ji-nan SHANDONG 250012,China,2.Department of Pharmacy,Shangdong Provincial Hospital(Western Division),Ji-nan SHANDONG 250022,China) |
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| Abstract: | Folate receptor is over-expressed in a variety of cancers but seldom expressed in normal tissues.Therefore,folate receptor-mediated antitumor drugs can be targeted specially to the folate receptor-positive tumor cell so as to avoid the cytotoxity to the normal cells and to improve the therapeutic effect.While, nano drug delivery systems would be useful for drugs to accumulate in tumor cells for their nanoscale size.This review provides the research and development about the nano drug delivery systems. |
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| Keywords: | folic acid folate receptor drug delivery systems targeted drug delivery drug carriers |
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