| 石杉碱甲缓释贴片和片剂人体药动学比较 |
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| 引用本文： | 吴婷,张军,许美娟,居文政,谈恒山. 石杉碱甲缓释贴片和片剂人体药动学比较[J]. 中国新药与临床杂志, 2011, 0(8) |
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| 作者姓名： | 吴婷 张军 许美娟 居文政 谈恒山 |
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| 作者单位： | 南京中医药大学附属医院临床药理科;中国人民解放军南京军区总医院; |
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| 基金项目： | 重大新药创制(2008ZX09312-004); 江苏省中药领军人才(LJ200906) |
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| 摘 要： | 目的比较2种石杉碱甲制剂在正常人体内的药动学情况。方法 20名健康受试者分为2组(每组10名),分别单剂量贴用石杉碱甲缓释贴片10 mg和口服石杉碱甲片0.2 mg后,用液相色谱-串联质谱法(LC-MS/MS)检测血浆中石杉碱甲浓度,并经DAS药动学程序进行数据处理,计算药动学参数。结果石杉碱甲缓释贴片与片剂的tmax分别为(40.2±13.2)、(0.6±0.3)h;t1/2分别为(28.4±7.4)、(13.6±1.3)h;ρmax分别为(0.7±0.4)、(1.9±0.5)μg.L-1;MRT0-t分别为(74.1±8.5)、(18.7±1.6)h;AUC0-t分别为(70.4±53.1)(0～168 h)、(19.9±2.7)(0～48 h)μg.h.L-1。结论石杉碱甲缓释贴片的药动学参数较普通片剂ρmax降低,tmax显著延长,t1/2延长,从而达到缓释效果。
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| 关 键 词： | 石杉碱甲 剂型 药动学 色谱法,高压液相 串联质谱法 |
Comparative pharmacokinetics of huperzine A sustained-release patches and tablets in normal volunteers |
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| WU Ting,ZHANG Jun,XU Mei-juan,JU Wen-zheng,TAN Heng-shan. Comparative pharmacokinetics of huperzine A sustained-release patches and tablets in normal volunteers[J]. Chinese Journal of New Drugs and Clinical Remedies, 2011, 0(8) |
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| Authors: | WU Ting ZHANG Jun XU Mei-juan JU Wen-zheng TAN Heng-shan |
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| Affiliation: | WU Ting1,ZHANG Jun1,XU Mei-juan1,JU Wen-zheng1,TAN Heng-shan2(1.Department of Clinical Pharmacology,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing JIANGSU 210029,China,2.General Hospital of Nanjing Military Command of PLA,Nanjing JIANGSU 210002,China) |
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| Abstract: | AIM To compare the pharmacokinetics of huperzine A sustained-release patches and tablets in healthy normal volunteers.METHODS Twenty healthy volunteers were divided into two groups(n = 10 for each group),and respectively received a single dose of sustained-release patches 10 mg and tablets of huperzine A 0.2 mg.The concentrations of huperzine A were determined by LC-MS/MS method and the pharmacokinetic parameters of huperzine A were calculated by DAS software.RESULTS The pharmacokinetic parameters of the su... |
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| Keywords: | huperzine A dosage forms pharmacokinetics chromatography high pressure liquid tandem mass spectrometry |
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