分化型甲状腺癌患者~(131)I-SPECT/CT显像的临床价值

目的探讨分化型甲状腺癌(differentiated thyroid carcinoma,DTC)患者131I-SPECT/CT显像的临床价值。方法 142例DTC患者甲状腺全切或次全切除术后行放射性131I碘内照射治疗208次,口服Na131I剂量3.7~11.1 GBq,5~7 d后行131I-WBS和131I-SPECT/CT显像。结果 131I-WBS发现DTC复发或转移灶真阳性245个、假阳性14个、假阴性48个、真阴性155个,131I-SPECT/CT显像发现DTC复发或转移灶真阳性427个、假阳性2个、假阴性14个、真阴性208个。DTC患者131I-WBS的灵敏度为83.6%,131I-SPECT/CT显像的灵敏度为96.8%,两者比较P<0.001,差异有统计学意义;31I-WBS的特异性为91.7%,131 I-SPECT/CT特异性是99.1%,两者比较0.01

Clinical value of ~(131)I-SPECT/CT image in patients with differentiated thyroid carcinoma

Objective To evaluate the clinical value of radioiodine-131 SPECT/CT image in patients with differentiated thyroid carcinoma.Methods Two hundred and eight cases of both whole body scans and SPECT/CT images were studied,which performed in 5～7 days after receiving 3.7～11.1 GBq of radioiodine-131 by oral intake for radioablation of thyroid remnants or recurrent and metastatic foci after a thyroidectomy in one hundred forty-two patients with differentiated thyroid carcinoma.Results The truth-positive,false-positive,false-negative and truth-negative of 131 I-SPECT/CT images for detecting DTC recurrent and metastatic foci were 427,2,14 and 208 respectively,but those of 131 I-WBS were 245,14,48 and 155.The sensitivity and accuracy of 131 I-SPECT/CT images in this study for detecting DTC recurrent and metastatic foci were 96.8% and 97.5%,which were significantly higher than 131 I-WBS(P<0.001,P<0.001),whereas those of 131 I-WBS were 83.6% and 86.5% respectively.The specificity of 131 I-SPECT/CT images for detecting recurrent and metastatic foci in DTC patients was higher than 131I-WBS(0.01