上海市普陀区1996～2003年间原发结核分枝杆菌感染的耐药性分析

目的了解我区1996~2003年间结核分枝杆菌原发耐药性。方法采用绝对浓度法进行异烟肼(INH)、利福平(RFP)、链霉素(SM)、乙胺丁醇(EMB)4种抗结核药物的耐受性测定。结果总原发耐药率由1996~1997年的14.6%上升至2002~2003年的19.7%(上升了34.9%)。耐INH、SM、RFP率由1996~1997年的8.9%、9.8%、5.7%上升至2002~2003年的15.3%、10.9%、8.0%,(分别上升了71.9%、11.2%和40.4%),耐EMB率由2.4%下降至0.7%,原发耐多药率2002~2003年为5.8%,与1996年相比,无明显上升。结论本区结核分枝杆菌原发耐药性呈上升趋势,耐多药菌株仍占一定比例。

Analysis of primary drug resistance of Mycobacterium tuberculosis in Shanghai Putuo district from 1996 to 2003 year

Objective To investigate the primary drug resistance of Mycobacterium tuberculosis (M.tuberculosis) in Sanghai Putuo district from 1996-2003. Methods Absolute concentration method was used for the detection of drug sensitivity to 4 antituberculsis (agents): isonicotinyl hydrazide(NH), rifampicin(RFP), streptomycin(SM) and ethambutol(EMB). Results The rate of total primary drug resistance increased from (14.6%) in 1996-1997 to (19.7%) in 2002-2003(increased (34.9%). The rates of primary drug resistance to INH, SM and RFP were (8.9%), (9.8%) and (5.7%) respectively in 1996-1997 and increased to (15.3%),(10.9%) and (8.0%) in 2002-2003 respectively (increased (71.9%), (11.2%) and (40.4%), while the rate of drug resistance to EMB was (2.4%) in 1996-1997, and decreased to (0.7%) in 2002-2003. The primary multi-drug resistance M.tuberculosis rate was (5.8%) in 2002-2003, a light increase compared with 1996. Conclusions The primary drug resistance of M.tuberculosis in Sanghai Putuo district from 1996 to 2003 was in a trend of increase, but multi-drug resistance is still a serious problem.