O型孕妇血清IgG抗AB效价测定的临床意义

目的对夫妻血型不合的O型孕妇进行血清IgG抗AB效价测定并初步探讨其临床意义。方法采用2-me裂解-37℃吸收-56℃释放-微柱凝胶法分别检测O型男性献血员血清和不同胎次孕妇的血清IgG抗AB效价。结果O型男性献血员血清IgG抗AB总阳性率为18．3％（11／60），且IgG抗A或抗B效价小于512者血清中均未检到IgG抗AB；孕妇组的总阳性率为52．8％（38／72），其中第一胎孕妇血清IgG抗AB阳性率为47．4％（18／38），非第一胎孕妇血清IgG抗AB阳性率为58．8％（20／34）。统计学结果表明，孕妇组与献血员组的IgG抗AB阳性率有显著性差异（P〈0．01）。结论IgG抗AB与妊娠可能密切相关，胎母血型不合的妊娠（包括流产），可能会导致O型孕妇血清IgG抗AB效价升高。通过IgG抗AB效价的动态测定有望对新生儿溶血病或者胎儿血型进行预测。

Clinical significance of anti-AB titer of pregnant women with blood group O

Objective To detect anti-AB(IgG) in sera of the pregnant women with blood group O whose husbunds' is not O,then to explore its clinical significances.Methods 60 cases male donors with blood group O and 72 cases pregant women with different pregnancy times were detected by micro-column gel test(MGT).Results The positive rate of the male doners group were 18.3%(11/60).What was necessarily metioned was the rates were zero when their anti-A(IgG) or anti-B(IgG) less than 512 in sera;It was 52.8%(38/72) in the pregnant women group(in which,first-time pregnancy group was 47.4%,non-first-time pregnancy group was 58.8%).Statistics results indicated there were significant difference between male donors group and the pregnant women group(P<0.01). Conclusion It was possible that there were relations between anti-AB(IgG) and pregnancy,and the latter(include abortion) could cause the former increase.There maybe were feasibilities to predict HDN or blood group for fetuses by dynamic detection of anti-AB(IgG).