血液灌流对重度有机磷农药中毒患者炎症因子影响的临床研究

目的探讨血液灌流治疗急性重度有机磷农药中毒的应用价值。方法选取急性重度有机磷农药中毒患者60例,分为灌流组(HP组)和非灌流组(非HP组),非HP组按常规予积极洗胃、导泻、催吐,并给予阿托品及氯磷定治疗。HP组在上述治疗基础上进行血液灌流治疗。观察全部病例的肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-10、IL1β、高敏C反应蛋白(hs-CRP)水平的变化。结果 HP组TNF-α、IL-6、IL-10、IL-1β、hs-CRP水平较对照组降低,差异有统计学意义(P0.05)。结论血液灌流可以清除重度有机磷农药中毒患者的部分炎症因子,对重度有机磷农药中毒患者的脏器损害有保护作用。

Clinical Research on the Effect of Hemoperfusion on the Cytokines in Treatment of the Patients with Acute Severe Organophosphorus Pesticide Poisoning

Objective To assess the efficacy of the hemoperfusion in the treatment of the patients with acute severe organophosphorus pesticide poisoning.Methods Sixty patients with acute severe organophosphorus pesticide poisoning were enrolled and divided into hemoperfusion group(HP group) and non-hemoperfusion group(non-HP group),the non-HP group only accepted traditional treatment including gastric lavage,catharsis,emetic,atropine and pralidoxime chloride,HP group were treated with both HP and traditional treatment at the same time.Observe all the patient'cytokine TNF-α、IL-6、IL-10、IL-1β、hs-CRP between HP-group and non-HP group.Results The HP groups'cytokine TNF-α、 IL-6、IL-10、IL-1β,hs-CRP of HP-group were lower than those of non-HP group(P<0.05).Conclusion Hemoperfusion can clear up some cytokines and protect the organ injury caused by organophosphorus pesticide poisoning.