Epidemiology and clinical presentation of shigellosis in children less than five years of age in rural Mozambique |
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Authors: | Mandomando Inácio Sigaúque Betuel Vallès Xavier Espasa Mateu Sanz Sergi Sacarlal Jahit Macete Eusébio Abacassamo Fátima Ruiz Joaquim Gascon Joaquim Kotloff Karen L Levine Myron M Alonso Pedro L |
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Affiliation: | Centro de Investiga??o em Saúde da Manhi?a, IDIBAPS/Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. inacio.mandomando@manhica.net |
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Abstract: | Rectal swabs were collected from 1354 children <5 years of age with diarrhea attending Manhi?a District Hospital and from 227 healthy community controls. Shigellosis incidence was high among children aged 12-47 months (488.4/10(5) child-years at risk). Fever and dysentery were prominent clinical findings. Shigella was more frequently isolated from cases than controls (6.7% versus 0.4%, P = 0.004), and from dysentery than nondysenteric diarrhea (24.1% versus 3.5%, P < 0.001). Shigella flexneri 2a, S. sonnei, and S. flexneri 6, were the most prevalent serotypes. |
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