| 低预处理剂量异基因外周造血干细胞移植治疗慢性粒细胞白血病 |
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| 引用本文： | 孙兆刚,滕清良,张春梅,李秀兰,黎爱华,张伯龙. 低预处理剂量异基因外周造血干细胞移植治疗慢性粒细胞白血病[J]. 泰山医学院学报, 2003, 24(4): 363-364 |
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| 作者姓名： | 孙兆刚 滕清良 张春梅 李秀兰 黎爱华 张伯龙 |
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| 作者单位： | 1. 泰山医学院第一教学医院,山东,泰安,271000
2. 中国人民解放军总医院,北京,100853 |
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| 摘 要： | 目的探讨低预处理剂量异基因外周血造血干细胞移植(allo-PRSCT)治疗慢性粒细胞白血病(CML)的治疗效果。方法对4例CML患者进行了低预处理剂量allo-PBSCT治疗并进行了临床观察。结果4例均成功植入(完全植入或混合型嵌合性植入)，1例出现IV aGVHD，存活3个月后死于重度cGVHD及多脏器功能衰竭；另外3例未出现严重移植并发症，1例10个月后失访，2例至今分别存活14个月、27个月。结论：低预处理剂量allo-PBSCI是一种根治CML更安全有效的方法。
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| 关 键 词： | 慢性粒细胞白血病 异基因外周血造血干细胞移植 低预处理剂量 |
| 文章编号： | 1004-7115(2003)04-0363-02 |
| 修稿时间： | 2003-03-11 |
Allogeneic peripheral blood stem cell transplantation with low dose pretreatment in chronic myelocytic leukemia |
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| SUN Zhao gang ,TENG Qing liang ,ZHANG Chun mei ,LI Xiu lan ,LI Ai hua ,ZHANG Bo long. Allogeneic peripheral blood stem cell transplantation with low dose pretreatment in chronic myelocytic leukemia[J]. Journal of Taishan Medical College, 2003, 24(4): 363-364 |
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| Authors: | SUN Zhao gang TENG Qing liang ZHANG Chun mei LI Xiu lan LI Ai hua ZHANG Bo long |
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| Affiliation: | SUN Zhao gang 1,TENG Qing liang 1,ZHANG Chun mei 1,LI Xiu lan 1,LI Ai hua 1,ZHANG Bo long 2 |
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| Abstract: | Objective: To study the effect of allogeneic peripheral blood stem cell transplantation (PBSCT) with low dose pretreatment in chronic myelocytic leukemia (CML). Methods: Four patients of CML were treated by PBSCT with low dose pretreatment. Results: All of 4 patients were successfully embeded (entirely or in a mixed pattern). One patient was alive 3 months and died because of severe graft verses host disease (GVHD) and multiple organ failure. One patient missed visiting at 10 months after PBSC. Two other patients were still alive for 14 and 27 months. Conclusion: PBSCT with low dose pretreatment is safety and effective. |
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| Keywords: | chronic myelocytic leukemia allogeneic peripheral blood stem cell transplantation low dose pretreatment |
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