| 苄青霉素亚砜对-甲氧基苄酯的合成研究 |
| |
| 引用本文： | 杨莉 徐满才 刘智凌. 苄青霉素亚砜对-甲氧基苄酯的合成研究[J]. 中国抗生素杂志, 2005, 30(10): 586-587,637 |
| |
| 作者姓名： | 杨莉 徐满才 刘智凌 |
| |
| 作者单位： | [1]湖南师范大学化学化工学院,长沙410081 [2]湖南化工研究院,长沙410007 |
| |
| 摘 要： | 以苄青霉素钾盐为原料，用低浓度CH3CO3H作氧化剂．所得苄青霉素亚砜以固体形式直接从溶液中结晶析出，再以对-甲氧基苄氯酯化，制得头孢类药物的母核7-苯乙酰胺基-3-氯甲基头孢烷酸对甲氧苄酯（GCLE）的关键中间体苄青霉素亚砜对-甲氧基苄酯，实验总收率82．6％。本工艺只使用一种有机溶剂，缩短了皮应时间，降低了成本，适合规模生产。
|
| 关 键 词： | 苄青霉素亚砜酯 头孢素菌 GCLE |
| 文章编号： | 1001-8689（2005）10-0586-02 |
| 收稿时间： | 2005-03-08 |
| 修稿时间： | 2005-03-08 |
Synthesis of benzylpenicillin sulfoxide p-methoxybenzyl ester |
| |
| Yang LI, Xu Man-cai, Liu Zhi-ling. Synthesis of benzylpenicillin sulfoxide p-methoxybenzyl ester[J]. Chinese Journal of Antibiotics, 2005, 30(10): 586-587,637 |
| |
| Authors: | Yang LI Xu Man-cai Liu Zhi-ling |
| |
| Affiliation: | 1 Department of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081 ; 2 Hunan Research Institute of Chemical Industry, Changsha 410007 |
| |
| Abstract: | Benzylpenicillin potassium salt was oxidized by low concentration peracetic acid,the product could precipitate directly from the solution.Benzylpenicillin sulfoxide p-methoxybenzyl ester,the key intermediate for the preparation of the new nucleus,7-benzylacetamide-3-chloromethyl-3-cepham-4-carboxylic acid(p-methoxybenzyl) ester(GCLE) was synthesized by esterification with p-methoxybenzyl chloride.The overall yield was 82.6%.Only one organic solvent was needed to achieve the process in a reduced time and low cost and also could be used for scale-up production. |
| |
| Keywords: | Benzylpicillin sulfoxide ester Cephalosporin GCLE |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
