| Abstract: | The state of membrane permeability for potassium and calcium ions was studied in bilayer phospholipid membranes (BPM) from the liver of rats with burns. A sharp increase in the conductivity of BPM was found under these circumstances. This process was accompanied by an increase in lipid peroxidation. Administration of -tocopherol (1 mg/kg body weight) restored these indices to normal. Model experiments with methyl oleate and cumyl hydroperoxide confirm the peroxide mechanism of injury to membrane formations.Department of Biochemistry, Erevan Medical Institute. Department of Biophysics, Central Research Laboratory, Erevan Postgraduate Medical Institute, Ministry of Health of the USSR. (Presented by Academician of the Academy of Medical Sciences of the USSR N. A. Fedorov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 87, No. 5, pp. 422–425, May, 1979. |
