Experimental treatment of chronic pelvic inflammatory disease in rats with acupoint injection of Astragalus parenteral solution] |
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| Authors: | Xue-feng Cai Zhang-lian Wang Li-fang Chen |
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| Institution: | The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China. cgc@mail.hz.zj.cn |
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| Abstract: | OBJECTIVE: To observe the effect of acupoint injection with astragalus parenteral solution in rat chronic pelvic inflammatory disease (CPID). METHODS: Fifty female Wistar rats were randomly divided into 6 groups: CPID model was induced in 4 groups, in addition to control group and false surgery group. The rats were given acupoint (Guanyuan and Zusanli) injection with astragalus parenteral solution and saline. The drug group was fed with Qianjinpian solutions. The histopathologic changes of uterus were observed and serum IL-2 and TNF-alpha levels detected. RESULT: The rats in the model group showed chronic inflammatory changes, the animals in astragalus parenteral injection group and Qianjinpian group showed little histopathological changes. The serum TNF-alpha levels in the model group were significantly higher than those in the normal group and the astragalus parenteral injection group; while the IL-2 levels in model group were significantly lower than those of other 5 groups. The TNF-alpha and IL-2 levels in astragalus parenteral injection group were similar to those of normal group. CONCLUSION: The treatment of chronic pelvic inflammatory disease with acupoint injection of astragalus parenteral solution might be effective. |
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