放线瑞香宁碱的解热镇痛作用

从青藤科植物黑吹风(Illigera sp)总生物碱中分离出一个单体,经化学鉴定命名为放线瑞香宁碱(actinodapbnine简称Ac)。分子式C_(18)H_(17)NO_4,为10-甲氧基-1,2-(次甲二氧基)-6-去甲阿朴菲-9-醇(图1)。动物实验表明,Ac具有解痉、镇痛、局麻及降低小鼠体温等作用,并证明其镇痛作用系非中枢性。本文进一步研究其镇痛作用和对不同动物正常

STUDIES ON THE ANTIPYRETIC AND ANALGESIC ACTIONS OF ACTINODAPHNINE

In this paper, the antipyretic and analgesic actions of actinodaphnine, isolated from Illigera SP, were studied. The results are as follows: 1. The normal body-temperature in mice, rats or rabbits was reduced by actinoaphnine ip; 2. The fever induced by colibacillus and peptone in rabbits was also markedly reduced by actinodphnine ip; 3. The writhing response in mice was inhibited and the pain threshold was markedly elevated by actinodaphnine ip; But the effect of actinodaphnine on the pain threshold in mice (i. c. v) was not obvious.These results indicate that: actinodaphnine had antipyretic and analgesic actions. The antipyretic action of actinodaphnine was recognized as increasing the loss of heat from the body-surface. The analgesic action (hot plate method) of actinodaphnine appears to be not of central nature, but related to reduction of the skin temperature of the palm of mice or to the production of local anesthesia.