恶性肿瘤相关生长因子（TSGF）在大肠癌辅助诊断中的临床价值

目的探讨恶性肿瘤相关生长因子（Tumor supplied growth of factors，TSGF）在大肠癌诊断中的临床应用价值。方法用生化比色法检测71例大肠癌患者、55例大肠良性肿瘤患者及100健康体检人员的血清中的TSGF浓度，并进行比较分析。结果大肠癌组TSGF浓度及阳性率（浓度为63．5-98×10^3U／L，平均浓度为81．5×10^3U／L，阳性率为71％）明显高于大肠良性肿瘤组（浓度为43-75×10^3U／L，平均浓度为57．2×10^3U／L，阳性率为7．4％）及健康体检组（浓度为40．5-73×10^3U／L，平均浓度为55．7×10^3U／L，阳性率为3％）；TSGF的阳性率与患者的年龄、性别和肿瘤的分期无关；TSGF诊断大肠癌的敏感度为71％高于CEA的敏感性（43．7％）。结论血清TSGF对大肠癌的早期诊断敏感性高于CEA，有助于大肠的辅助诊断，尤其是大肠癌早期阶段的诊断。

Clinical value of tumor supplied growth factors in the diagnosis of colorectal cancer

Objective To investigate the diagnostic value of tumor supplied growth factors （TSGF） in patients with colorectal eaneer. Methods The content of TSGF was determined from 71 colorectal cancer cases, 55 benign tumor and 100 normal persons with colorimetry of biochemistry. Results TSGF concentration and positive rate were significantly higher in colorectal canecr cases （81.5×10^3U/L/71% ） than that of normal controls and patients with benign tumor （55.7×10^3U/L/3% and 57.2×10^3U/L/7. 4% ）. The positive rate of TSGF was independent of patient＇s age ,sex and stage of colorectal canecr. The diagnostic sensitivity of TSGF was 71% for colorectal canecr, higher than 43.7 % of CEA. Conclusion TSGF is more sensitive than CEA, and may be useful for the early diagnosis of colorectal cancer.