2型糖尿病患者心血管自主神经功能与QT离散离及室性心律失常关系的研究

为探讨2型糖尿病患者心血管自主神经功能与QT离散度（QTd)及室性心律失常的关系。随机选取2型糖尿病患者60例，按标准心血管自主神经功能试验（下简称神功试验）结果分为阳性（异常）组35例和阴性组25例，另取35例健康人作为对照组。分别测定QTd和经心率校正的QTd(QTcd)，同时记录24小时室性心律失常的发生率，进行对比分析。结果 60例糖尿病患者心血管神功试验的阳性率为58.3%，阳性组的QTd、QTcd较阴性组明显延长，室性心律失常及复杂性室性心律失常的发生率明显增高（P均＜0.01)。认为糖尿病患者的心血管自主神经功能与QTd与QTcd明显增加，其可能是导致室性心律失常和心源性猝死的重要原因之一。

Relationship amongcardiovascular autonomic function and QT dispersion and ventricular arrhythmia of patientswith type 2 diabetes mellitus

To investigate the relationship among cardiovascular autonomicfunction（CAF），QT dispersion（QTd）and ventricular arrhythmia of patients with type 2 diabetes mellitus（DM）.60 patients with type? 2 DM and 35 heathly controls were in volved in the study.According to the results of standard test of CAF，the patients with DM were divided into two groups including positive group（35）and negative group（25）.QTd and QTc dispersion（QTcd）and incidence of ventricular arrhythmia in 24 hours were estimated and analysed.Results showed that the incidence of diabetic autonomic neuropathy in type 2 DM was 58.3％，which correlated with duration of diabetic history，QTd，QTcd and incidence of ventricular arrhythmia obviously increased in type 2 DM with abnormal CAF（p＜0.01）than those in negative group.It suggests that the positive rate of diabetic autonomic neuropathy in type 2 DM patients is high，QTd and QTcd are significantly increased in DM patients with abnormal CAF，this may be one of causes that give rise to ventricular arrhythmia and sudden death.