| 表面活性剂在超临界流体萃取中的作用 |
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| 引用本文： | 陈斌,杨根金,贾暖,刘荔荔,吴玉田. 表面活性剂在超临界流体萃取中的作用[J]. 第二军医大学学报, 2000, 21(5): 463-465 |
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| 作者姓名： | 陈斌 杨根金 贾暖 刘荔荔 吴玉田 |
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| 作者单位： | 1. 第二军医大学药学院药物分析教研室,上海,200433
2. 第二军医大学药物分析测试中心,上海,200433 |
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| 基金项目： | 国家自然科学基金资助项目!(39770904) |
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| 摘 要： | 目的：考察表面活性剂提高超临界流体萃取（ＳＦＥ）效率的作用。方法：以麻黄碱为研究对象，用含５％苯基硅氧烷交联毛细管柱进行分析，考察琥珀酸二辛酯磺酸钠（ＤＳＳ）、十二烷基硫酸钠（ＳＤＳ）、１－庚烷基磺酸钠（ＳＨＳ）和羧甲基纤维素钠（ＣＭＣ－Ｎａ）４种表面活性剂对超临界流体溶解性的影响。结果：发现ＤＳＳ，ＳＤＳ，ＳＨＳ及ＣＭＣ－Ｎａ分别能够提高萃取效率２４６．８％，１２３．４％，８３．０％和５３．２％
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| 关 键 词： | 超临界流体萃取 表面活性剂 麻黄碱 |
| 修稿时间： | 】 |
Role of surfactant in supercritical fluid extraction |
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| CHEN Bin,YANG Gen-Jin,JIA Nuan,LIU Li-Li,WU Yu-Tian. Role of surfactant in supercritical fluid extraction[J]. Former Academic Journal of Second Military Medical University, 2000, 21(5): 463-465 |
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| Authors: | CHEN Bin YANG Gen-Jin JIA Nuan LIU Li-Li WU Yu-Tian |
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| Abstract: | Objective: To observe the effect of surfactant in enhancing the efficiency of supercritical fluid extraction (SFE). Methods: Dioctyl sodium sulfosuccinate (DSS), sodium dodecyl sulfate (SDS), 1 heptanesulfonate (SHS), CMC Na were used as the surfactants, their influences on extraction of ephedrine by SFE were studied by 5% phenyl cross silicon capillary gas chromatography (CGC). Results: DSS, SDS, SHS and CMC Na enhanced the efficiency of SFE by 246.8%, 123.4%, 83.0% and 53.2% respectively, which was due to their molecular structure, the more liposoluble parts they have, the higher the efficiency. DSS had the best effect of solubilization among these surfactants. Conclusion: This method can obviously increase the solubilization of supercritical CO 2. It offers a valuable way for SFE of alkaloid. |
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| Keywords: | supercritical fluid extraction surfactant ephedrine |
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