The relationship between morphine, aspartic acid and L-asparaginase in rats |
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Authors: | Hikmet Koyuncuo?lu Meral Keyer-Uysal Kemal Berkman Mehmet Güngör Ece M Genç |
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Institution: | Department of Pharmacology and Clinical Pharmacology, Istanbul Medical Faculty, Çapa-Istanbul, Turkey |
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Abstract: | Morphine and aspartic acid were administered separately and in combination to 80 rats divided into 8 groups. Ten and 20 min following the injections, brain, liver and kidney L-asparaginase activity was determined. Morphine decreased brain and liver L-asparaginase activity and increased that of kidney. Aspartic acid completely antagonized the effect of morphine. Additionally 500 IU/kg L-asparaginase and 5 or 10 mg/kg morphine were i.v. injected into 56 rats divided into 5 groups. L-Asparaginase, which, in turn, increased motor activity, antagonized the morphine-induced hypoactivity and analgesia. These results support our previous findings. |
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Keywords: | L-Asparaginase administration Aspartic acid Hypoactivity Analgesia L-Asparaginase activity Morphine |
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