| 超氧阴离子对缺氧大鼠肺内动脉乙酰胆碱舒张反应的影响 |
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| 引用本文： | 李俊发 郑永芳. 超氧阴离子对缺氧大鼠肺内动脉乙酰胆碱舒张反应的影响[J]. 基础医学与临床, 1992, 12(3): 53-56 |
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| 作者姓名： | 李俊发 郑永芳 |
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| 作者单位： | 中国医学科学院基础医学研究所，中国医学科学院基础医学研究所，中国医学科学院基础医学研究所 北京 100005，北京 100005，北京 100005 |
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| 摘 要： | 本文应用微量生物测定法观察超氧阴离子在慢性缺氧影响肺内动脉乙酰胆硷舒张反应中的作用。发现慢性缺氧可明显减弱大鼠肺内动脉的ACh内皮依赖性舒张,超氧化物歧化酶则可使此舒张反应恢复到正常水平。利用黄嘌呤—黄嘌呤氧化酶系统产生氧自由基(主要为O_2~((?))可削弱正常大鼠肺内动脉的ACh舒张反应,同样SOD可保护其免遭外源性氧自由基的损伤。结果表明慢性缺氧使肺血管氧自由基(尤其是O_2~((?))产生增多是大鼠肺内动脉ACh舒张反应受到损伤的原因之一。
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| 关 键 词： | 肺内动脉 超氧阴离子 乙酰胆碱 |
The Effect of Superoxide on ACh-Induced Relaxation of Intrapulmonary Artery in Hypoxic Rats |
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| Li Junfa Zheng Yongfang Deng Xixian. The Effect of Superoxide on ACh-Induced Relaxation of Intrapulmonary Artery in Hypoxic Rats[J]. Basic Medical Sciences and Clinics, 1992, 12(3): 53-56 |
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| Authors: | Li Junfa Zheng Yongfang Deng Xixian |
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| Abstract: | To investigate the ro]e of superoxide (O2- ) in the attenuation of acetycholine-indueed pulmonary arterial relaxation, microbioassay method was used. To further dete rmine the role of O2- in the attenuation of relaxation in response to ACh,intra-pulmonary artery rings from C (control) group were exposed to a superoxide radical generating system of xanthine + xanthine oxidase (X+XO)in vitro.X + XO treatment caused a significant decrease in the ACh relaxation .Preteratment of rings with Cu-Zn SOD protected against the loss of ACh-induced relaxation .These observations suggest that release of superoxide( O2-) during chronic hypoxia may be the basis of loss of ACh-induced intrapulmonary arterial relaxation. |
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| Keywords: | Intrapulmonary artery ACh-induced endothelium-dependent relaxation superoxide(O2-) chronic hypoxic pulmonary hypertension |
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