烧伤患者尿FDP,LZM的变化及临床意义

本文观察了44例四组不同烧伤面积患者的尿FDP(fibrin degradation)、尿LZM(Lysozyme),并分析了与伤情、败血症或死亡的关系。测试结果显示:随着伤情的增重尿FDP、LZM上升幅度逐渐增高,10％以下烧伤面积尿FDP、LzM均在正常范围,分别为0.24μg/ml、4.61μg/ml,而C、D组尿FDP上升为1.65μg/ml、3.5μg/ml;尿LZM30.5μg/ml、99.24ug/ml,两者呈正相关,而且与尿蛋白、尿素氮的上升水平也呈正相关。尿FDP上升1.248ug/ml,尿LZM上升51μg/ml以上提示肾功能有衰竭情况,特别是尿FDP上升4.992,尿LZM上升91μg/ml以上标志予后不佳。本检测对判断病情,评价治疗效果,予示肾功情况、败血症的发生与病情转归有一定临床价值,而且较敏感。

Urine FDP and lysozyme in burn patients

This paper reported the relationship between the levels of urine FDP and lysozyme and the clinical state in burn patients. The patients were devided into 4 groups according to their burn surface, i. e. group A (burn surface less than 10%), group B (11-30%), group C (31-50%,) and group D (51-96%). The levels of urine FDP and lysozyme gradually increased, in proportion to the severities of the burn, for example the levels keeping in normal range in group A but increased markedly in group C or D (1.65 or 3.5ug/ml and 30.5 or 99.24 ug/ml respectively). Another interesting phenomenon is that the prognosis of burn patients was very poor when the levels of FDP or lysozyme reached to 4.99 ug/ml or 91 ug/ml respectively. Urine FDP and lysozyme detection seems to be of value in estimating the severity of burn and predicting the renal functions and the presence of septesis following burn injury.