Inhibition of bone resorption in culture by (+)-catechin |
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| Authors: | J M Delaissé Y Eeckhout G Vaes |
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| Affiliation: | 1. Department of Biotechnology, Faculty of Agro-Industry, Kasetsart University, Chatuchak, Bangkok, 10900, Thailand;2. Thailand Institute of Scientific and Technological Research (TISTR), KlongLuang, Pathumthani, 12120, Thailand;3. Department of Agriculture, Ministry of Agriculture and Cooperatives, 50 Phaholyothin Road, Ladyao, Chatuchak, Bangkok, 10900, Thailand;4. Center for Advanced Studies for Agriculture and Food, Kasetsart University Institute for Advanced Studies, Kasetsart University, (CASAF, NRU-KU Thailand), Bangkok, 10900, Thailand;1. Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal;2. Radio-Television-Film, College of Communication, The University of Texas at Austin, 2504 Whitis Ave Stop A0800, Austin, TX 78712-1067, USA;3. Department of Sociology, Faculty of Humanities, University of Porto, Via Panorâmica, s/n, 4150-564 Porto, Portugal;1. The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada;2. Departments of Medicine and Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada;1. Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India;2. Graduate School of Engineering, Kyushu University, 744 Motooka Nishi-ku, Fukuoka 819-0395, Japan;3. Physical Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India;4. Institute for Materials Chemistry and Engineering (IMCE), Kyushu University, 744 Motooka Nishi-ku, Fukuoka 819-0395, Japan;1. Institute for Health and Sport, Victoria University, Melbourne, Australia;2. Department of Sociology, University of Amsterdam, the Netherlands;3. Utrecht University School of Governance, Utrecht University, the Netherlands;4. Faculty of Education, Monash University, Australia;1. School of Ecology and Nature Conservation, Beijing Forestry University, P.O. Box 61, Beijing, 100083, PR China;2. Westerdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands |
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| Abstract: | A pretreatment with (+)-catechin renders embryonic mouse calvaria in culture resistant to the action of bone resorbing agents, either parathyroid hormone (PTH), prostaglandin E2 or retinoic acid, and inhibits in a parallel way the enhanced excretion of N-acetyl-beta-glucosaminidase, a reference lysosomal enzyme, induced by these agents; it has, however, no effect on the small spontaneous leakage of lactate dehydrogenase from the explants. Moreover, the resorption induced in calvaria by a pretreatment with PTH or retinoic acid is inhibited by a further culture with catechin. This inhibition of bone resorption is discussed in relation with the collagen-stabilizing properties of (+)-catechin. |
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