| p16基因在乳腺癌中的表达及临床意义 |
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| 引用本文： | 宫向前,寿楠海,张永生,王启堂. p16基因在乳腺癌中的表达及临床意义[J]. 中华肿瘤防治杂志, 2002, 9(2): 142-143 |
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| 作者姓名： | 宫向前 寿楠海 张永生 王启堂 |
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| 作者单位： | 1. 山东大学齐鲁医院普外科,山东,济南,250012
2. 青岛大学医学院第二附属医院乳腺外科,山东,青岛,266071 |
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| 摘 要： | 目的 :研究p16基因在乳腺癌中的表达及临床意义。方法 :应用免疫组织化学方法 (SABC法 ) ,检测了 92例乳腺癌组织p16基因蛋白的表达。结果 :发现p16基因表达阳性率为 4 5 7% (42 /92 ) ,p16基因表达与腋淋巴结转移无关 ;但p16阳性者远隔转移率 14 3% (6 / 4 2 )低于p16阴性组 34%(17/ 5 0 ,P <0 0 5 )。本组p16基因表达与疾病缓解期无关。结论 :提示p16基因在乳腺癌病程中起重要作用 ,对筛选乳腺癌术后高危转移患者 ,加强随访诊治有一定参考意义。
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| 关 键 词： | 乳腺肿瘤/遗传学 基因 p16 免疫组织化学 |
| 文章编号： | 1009-4571(2002)02-0142-02 |
| 修稿时间： | 2001-12-05 |
Clinical Significance of p16 Expression in Breast Carcinoma |
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| GONG Xiang qian,SHOU Nan hai,ZHANG Yong sheng,et al.. Clinical Significance of p16 Expression in Breast Carcinoma[J]. Chinese Journal of Cancer Prevention and Treatment, 2002, 9(2): 142-143 |
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| Authors: | GONG Xiang qian SHOU Nan hai ZHANG Yong sheng et al. |
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| Affiliation: | GONG Xiang qian,SHOU Nan hai,ZHANG Yong sheng,et al.Department of General Surgery,Qilu Hospital of Shandong University,Jinan 250012,China |
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| Abstract: | Objective To study the clinical significance of p16 expression in breast carcinoma.Methods The expression of p16 gene in human breast carcinomas was studied by immunohistochemistry(SABC)to investigate the relationship between the expression and the clinical pathologic parameters.Results The positive rate of p16 was 45 7%(42/92).While no relationship was found between the expression of p16 and lymph node metastasis,the patients with negative expression of p16 have higher incidence of distant metastasis (34%, 17/50) than the positive group(14 3%,6/42), P <0 05.But no correlation was found between p16 and disease free period.Conclusions These findings suggest that the patients with negative p16 expression may be associated with metastasis resulting in poor prognosis. |
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| Keywords: | breast neoplasms/genetics genes p16 immunohistochemistry |
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