蒲地蓝联合利巴韦林治疗小儿手足口病疗效观察

目的 观察蒲地蓝联合利巴韦林对手足口病的治疗效果.方法 手足口病患者70例,随机分为两组：治疗组（蒲地蓝联合利巴韦林）和对照组（单用利巴韦林）.观察两组患者的疗效、皮疹完全消失时间、发热消退时间及不良反应.结果 治疗组治愈率及有效率分别为57%、94%,对照组治愈率及有效率分别为43%、86%,两组治愈率及有效率比较差异有统计学意义（均P＜0.05）.治疗组较对照组在手足皮疹消失、口腔皮疹消失及发热消退时间明显缩短,差异有统计学意义（均P＜0.05）.两组患者均未发现明显不良反应.结论 较单用利巴韦林,蒲地蓝联合利巴韦林治疗手足口病明显提高了治愈率,缩短了皮疹完全消失时间及发热消退时间,是治疗手足口病的一种安全、有效的方法.

The clinical effect of Pudilan combined with ribavirin in treatment of children with HFMD

Objective To investigate the effect of Pudilan combined with ribavirin in treatment of the hand-foot-mouth disease(HFMD). Methods 70 patients were randomly divided into treatment group ( Pudilan combined with ribavirin) and control group (ribavirin only). Results Compared with the control group,the cure rate and the effective rate in treatment group had statistically significant difference ( all P ＜ 0.05 ). Compared with the control group,the rash disappeared time and the fever subsiding time in treatment group were shorter obviously ( all P ＜0. 05 ). The both groups had no obvious side effect. Conclusion Pudilan combined with ribavirin in the treatment of HFMD had a good therapeutic effect and were a safe and effective method.