| 2型糖尿病患者血清胰岛素样生长因子Ⅰ及其结合蛋白与大血管并发症的关系 |
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| 引用本文： | 张贺芳,苏胜偶,蔡志刚. 2型糖尿病患者血清胰岛素样生长因子Ⅰ及其结合蛋白与大血管并发症的关系[J]. 中华糖尿病杂志, 2007, 15(1): 40-41 |
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| 作者姓名： | 张贺芳 苏胜偶 蔡志刚 |
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| 作者单位： | 河北医科大学第二医院内分泌科，河北医科大学第二医院内分泌科，河北医科大学第二医院内分泌科 050000石家庄，河北医科大学中医院内分泌科，050000石家庄，050000石家庄 |
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| 摘 要： | 2型糖尿病(T2DM)合并大血管病变者血清游离胰岛素样生长因子Ⅰ(IGF-I)水平较无大血管病变组降低(P<0·01),胰岛素样生长因子结合蛋白1浓度与WHR、胰岛素抵抗指数呈负相关。表明低IGF-I可能参与糖尿病大血管并发症的发生。胰岛素样生长因子结合蛋白1的浓度反映了胰岛素抵抗状态。
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| 关 键 词： | 胰岛素样生长因子Ⅰ 胰岛素样生长因子结合蛋白质1 糖尿病,2型 糖尿病血管病变 胰岛素抵抗 |
| 收稿时间： | 2005-01-10 |
| 修稿时间： | 2005-01-10 |
The relationship of insulin-like growth factor-I and IGF-binding protein-1 with macrovascular complications in type 2 diabetic patients |
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| ZHANG He-fang,SU Sheng-ou,CAI Zhi-gang. The relationship of insulin-like growth factor-I and IGF-binding protein-1 with macrovascular complications in type 2 diabetic patients[J]. CHINESE JOURNAL OF DIABETES MELLITUS, 2007, 15(1): 40-41 |
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| Authors: | ZHANG He-fang SU Sheng-ou CAI Zhi-gang |
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| Affiliation: | Department of Endrocrinology, The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, China |
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| Abstract: | The level of serum free insulin-like growth factor-I (IGF-I) was significantly lower in type 2 diabetic patients with macrovascular complications than the patients without macrovascular complications (P<0.01), IGF-binding protein-1 was negatively correlated with waist-hip ratio and HOMA-IR index, suggesting that the lower concentration of IGF-I may be involved in the development of diabetic macrovascular complications. The concentration of IGFBP-1 may reflect insulin resistance status. |
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| Keywords: | Insulin-like growth factor I Insulin-like growth factor binding protein 1 Diabetes millitus type 2 Diabetic angiopathies Insulin resistance |
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