Effects of Concanavalin A on the isolated perfused rat liver |
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Authors: | R. Kroker D. Hegner |
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Affiliation: | (1) Institut für Pharmakologie, Toxikologie und Pharmazie, Fachbereich Tiermedizin der Universität München, Veterinärstr. 13, D-8000 Müchen 22, Federal Republic of Germany |
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Abstract: | Summary In the isolated perfused liver, Concanavalin A provoked a significant decrease of flow rate within 2 to 4 min which was dose-dependent and could be partly inhibited by specific antagonists.Furthermore it was found that the lectin led to a decline of the respiration, an increase of the lactate/pyruvate ratio and a release of the transaminases into the medium. It was suggested that Concanavalin A displaced endothelial cells in the liver capillaries, which occluded the vessels and decreased the flow rate. The decreased respiration was considered to be secondary to this effect. |
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Keywords: | Concanavalin A Perfused Rat Liver Flow Rate Metabolic Functions Histology |
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