| 铂类抗癌药与LILAK细胞联合杀伤人肺腺癌细胞的初步研究 |
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| 引用本文： | 付体辉,谢之荣.铂类抗癌药与LILAK细胞联合杀伤人肺腺癌细胞的初步研究[J].癌症,1995,14(6):438-440. |
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| 作者姓名： | 付体辉 谢之荣 |
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| 作者单位： | 四川省成都肿瘤研究所 |
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| 摘 要： | 应用ＳＰＣ－Ａ１人肺腺癌细胞系研究了顺铂和上次后的细胞毒效应及其与人外周血ＬＩＬＡＫ细胞的联合效应及机制结果表明：经一定浓度的顺铂或卡铂作用一定时间后，ＳＰＣ－Ａ１细胞可受不同程度的杀伤。经１μｇ／ｍｌ的顺铂处理２４小时，洗去药物后加入ＬＩＬＡＫ细胞，ＳＰＣ－Ａ１细胞被明显杀伤，与未经顺铂处理的对照组相比Ｐ〈０．００１；而卡铂在同样条件下却无此效应。
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| 关 键 词： | 顺铂 卡铂 LILAK细胞 肺肿瘤 腺癌 |
PRELIMINARY STUDY OF COMBINED EFFECTS OF CISPLATIN OR CARDOPLATIN AND
LI LAK CELLS ON LUNG ADENOCARCINOMA CELLS |
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| FU Ti hui XIE Zhi,rong DENG Bi fang.PRELIMINARY STUDY OF COMBINED EFFECTS OF CISPLATIN OR CARDOPLATIN AND
LI LAK CELLS ON LUNG ADENOCARCINOMA CELLS[J].Chinese Journal of Cancer,1995,14(6):438-440. |
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| Authors: | FU Ti hui XIE Zhi rong DENG Bi fang |
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| Abstract: | The effects of cisplatin(CDDP),carboplatin(CBDCA) , lectin
induced lymphokineactivated killer(LI LAK)cells and their
combination on killing SPC A1, a human lungadenocarcinoma cell line
, Was investigaled. The results showed that after 48h exposure of SPC
Alcells to CDDP or CBDCA , both drugs could kill the target cells in
a dose dependent manner.Pretreatment of the target cells with
CDDP,but not with CBDCA,could markedly increase thesusceptibility of
the tumor cells to lysis by LI LAK cells.Because the susceptibility
of CDDP pretreated target cells to tumor necrosis factor(TNF)was
also enhanced, it was supposed that thisfactor might be one of
important mechanisms in killing CDDp pretreated SPC Al cells bv LI
LAK cells. |
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| Keywords: | Cisplatin Carboplatin LI LAK cells Lung tumor Adenocarcinoma TNF |
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