曲美他嗪治疗慢性充血性心力衰竭的临床观察

目的 观察曲美他嗪（trimetazidine，TMZ）对慢性充血性心力衰竭患者的临床药效及不良反应。方法 115例慢性充血性心力衰竭（NYHA心功能分级Ⅱ～Ⅳ级）患者随机分为两组。对照组（n=50例）应用常规药物，曲美他嗪组（n=65）在常规药物治疗的基础上加用曲美他嗪，用药期12周，定期门诊随访观察治疗前后心功能分级及超声心动图检查等。结果 曲美他嗪组总有效率（92．3％）明显优于对照组（66．0％）（P〈0.01）；曲美他嗪能明显改善慢性充血性心力衰竭患者临床症状和体征，左室射血分数（LVEF）和左室短轴缩短率（FS）明显提高（P〈0．01或0．05），且无严重不良反应出现。结论 慢性充血性心力衰竭患者在常规治疗基础上，加用曲美他嗪可进一步改善心功能，对治疗慢性充血性心力衰竭是一种安全有效的方法。

The efficacy of trimetazidine in chronic congestive heart failure

Objective To observe the clin ic al effects and side effects of trimetazidine in chronic congestive heart failure patients.Methods 115 congestive heart failure patients were ra ndomly divided into two groups.The control group(n=50) was given the routine medicine.The trimetazidine group(n=65) was administ ered trimetazidine on the basis of routine treatment.The therapy period was 12 w eeks.We observed the heart functional classification and echocardiography regula rly.Results The total effect rate of trimetazidine group was 92 .3%.It had better outcome than the control group(66.0%,P<0.01). Trimetazidine could improve the signs and symptoms of chronic congestive heart f ailure.The left ventricular ejection fraction and short axis shortening rate wer e improved significantly(P<0.01 or 0.05).There was no serious s ide effect in the trimetazidine group.Conclusion Trimetazidine may improve the heart function of chronic congestive heart failure patients on t he basis of routine treatment,which is a safety and effectual method to treat ch ronic congestive heart failure.