| Construction and identification of a retroviral vector of bcl-2 mRNA-cleaving ribozyme gene |
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| 引用本文： | 赵永同,朱峰,王成济. Construction and identification of a retroviral vector of bcl-2 mRNA-cleaving ribozyme gene[J]. 中国人民解放军军医大学学报, 1997, 0(3) |
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| 作者姓名： | 赵永同 朱峰 王成济 |
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| 作者单位： | Department of Biochemistry and Molecular Biology，Fourth Military Medical University，Xi'an，710032 |
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| 摘 要： | Ribozyme(RZ)isanRNAwithenzymeactivity.ThediscoveryofRZprovidedanotherspecificmethodforgenetherapy.VariousspecificRZsweredesignedtoblocktheexpressionofharmufulgenes,basedonthetrans--cleavingactivityofRZ.hcf--2isoneoftheapoptosisrelatedoncogenesL'],whichrenderthecellresistanttoX--ray['jandchemotherapyL',#j.hcf--2cansuppresstheprogrammedcelldeathorapoptosisofcentralnervoussystemandplaysacertainroleinimmunogenesisandneurogenesis['].AccordingtoHaseloff'smodelofribozyme,ageneofhammarheadRZ,wh…
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Construction and identification of a retroviral vector of bcl-2 mRNA-cleaving ribozyme gene |
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| Zhao Yongtong,Zhu Feng, Wang Chengji. Construction and identification of a retroviral vector of bcl-2 mRNA-cleaving ribozyme gene[J]. Journal of Medical Colleges of PLA(China), 1997, 0(3) |
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| Authors: | Zhao Yongtong Zhu Feng Wang Chengji |
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| Abstract: | |
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| Keywords: | bcl-2 RNA catalytic retroviral vector |
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