Association of a functional BDNF polymorphism and anxiety-related personality traits |
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Authors: | Undine E Lang Rainer Hellweg Peter Kalus Malek Bajbouj Kirsten P Lenzen Thomas Sander Dieter Kunz Jürgen Gallinat |
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Institution: | (1) Department of Neurology, University of Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany;(2) Clinic for Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany;(3) Clinic for Psychiatry and Psychotherapy, Charité Medicine Berlin, Campus Charité Mitte, Berlin, Germany;(4) Gene Mapping CenterMax-Delbrück-Centrum, Berlin, Germany;(5) Psychiatrische Universitätsklinik der Charité im St. Hedwig-Krankenhaus, Turmstrasse 21, 10559 Berlin, Germany |
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Abstract: | Rationale Converging lines of evidence point to brain-derived neurotrophic factor (BDNF) as a factor in the pathophysiology of depression. Recently, it was shown that the Val allele of the BDNF Val66Met substitution polymorphism showed a significant association with higher mean neuroticism scores of the NEO-Five Factor Inventory (NEO-FFI) in healthy subjects, and previous studies suggested the Val allele to be increased in bipolar disorder families. The association to anxiety-related traits has not been investigated so far.Methods We tested a total of 343 unrelated subjects of German descent (171 male, 172 female, age: 39.0±14.6 years) who were carefully screened for psychiatric health. The self-ratable State–Trait Anxiety Inventory (STAI), which allows anxiety to be quantified as a comparatively stable personality trait, and the NEO-Five Factor Inventory (NEO-FFI) was applied.Results In the trait-related anxiety score, a significant (F=3.2, df=2, p<0.042) effect of the genotype was observed with higher levels of trait anxiety in Val/Val (35.0±7.4) compared to Val/Met (33.4±6.5) and Met/Met (32.0±4.6) genotypes. The NEO neuroticism scores were also higher in Val/Val (29.5±7.0) than in Val/Met (28.4±6.5) or Met/Met (26.8±5.8) genotype, but not at a significant rate.Conclusions Our findings support the hypothesis that anxiety- and depression-related personality traits are associated with the BDNF polymorphism although the explained variance is low. |
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Keywords: | Brain-derived neurotrophic factor (BDNF) Polymorphism Healthy volunteers Neuroticism NEO-five factor inventory (NEO-FFI) Anxiety State and trait anxiety inventory (STAI) |
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