Ⅰ期原发性肝癌三维适形放疗的疗效评价和预后多因素分析

 目的 评价三维适形放疗（3-dimensional conformal radiation therapy,3-DCRT）对Ⅰ期原发性肝癌治疗疗效及其影响预后的因素分析。方法 对41例Ⅰ期原发性肝癌患者行三维适形放疗，用kaplan—Meier统计累积生存率、COX回归模型对预后进行单、多因素分析。结果 1、2、3年累积生存率分别为95．1％、90．2％、80．5％。平均生存时间49．5月。中位生存时间56个月。治疗副反应轻微。多因素回归分析显示仅肿瘤数目对患者生存期的影响有统计学意义（P〈0．05）。结论 三维适形放疗对Ⅰ期原发性肝癌患者的治疗是安全、有效的手段，肿瘤数目、肿瘤直径是影响预后的主要因素。

Therapeutic Effects Evaluation of Three-dimensional Conformal Radiotherapy for Stage Ⅰ Primary Hepatocellular Carcinoma and Multi-factors Analysis of the Prognosis

Objective 　To evaluate the therapeutic effect s of 3-dimensional conformal radiationtherapy for small hepatocellular carcinoma and analyze the prognostic factors. Methods 　Forty-one cases of small hepatocellular carcinoma were t reated with three-dimensional conformal radiotherphy , The Kaplan-Meier was used to evaluate the survival rates ,and the COX regression model was used to analysis single and multi-factors of the prognosis. Results 　The overall 1- , 2-, 3-year survival rate were 95. 1 %、90. 2 %、80. 5 % respectively. Mean survival time was 49. 5 months , Media survival time was 56 months. The side effects of radiotherapy could be tolerated. Multi-factors analysis revealed that the number and the diameter of tumor were independent prognostic factors affecting the patient s’survival ( P < 0. 05) . Conclusion 　The results suggest that three-dimensional conformal radiotherapy for Stage Ⅰ hepatocellular carcinoma is a relatively safe and effective method. The number and the diameter of tumor were independent prognostic factors affecting the patient s’survival.