糖尿病大鼠视网膜微血管的重建及某些药物对其的影响

目的：研究糖尿病大鼠视网膜微血管的重建。方法：用链脲佐菌素（ＳＴＺ）诱导ＳＤ大鼠建立糖尿病动物模型，运用视网膜消化铺片和图像分析方法观测糖尿病大鼠视网膜微血管的重建，及非酶糖化抑制剂和活血化瘀中药对其重建的影响。结果：在８周时毛细血管宽度即有显著性变化（Ｐ〈０．０５），非酶糖化抑制剂和活血化瘀中药治疗组在８～１２周后与糖尿病组有显著性差异（Ｐ〈０．０５）。结论：（１）糖尿病促进了视网膜微血管的形态

Remodeling of retinal microvessels in STZ-induced diabetic rats and medical influence

Objective: To observe the remodeling of diabetic microvessels in diabetic rats. Methods: Diabetic animal models were induced by STZ on SD rats. The rats were treated with nonenzymatic glycosylation inhibitor and blood flow activating and stasis removing traditional Chinese medicine to evaluate the remodeling of diabetic retinal microvessels by trypsin digestion and figure analysis. Results: At 8 weeks, significant alteration of retinal capillary width in diabetic rats were observed( P <0.05). At 8 12 weeks,the rats treated with nonenzymatic glycosylation inhibitor and traditional Chinese medicine exhibited statistical significance ( P <0.05) to diabetic rats. Conclusion: (1) Remodelings of retinal microvessels are accelerated in diabetic rats and they are correlated positively. (2) Nonenzymatic glycosylation inhibitor and blood flow activating and stasis removing traditional Chinese medicine have effects of preventing and treating diabetic retinopathy.